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Amy M. Ford
Researcher at Eli Lilly and Company
Publications - 4
Citations - 2508
Amy M. Ford is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: FGF21 & Transgene. The author has an hindex of 4, co-authored 4 publications receiving 2263 citations.
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Journal ArticleDOI
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Journal ArticleDOI
Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.
Anja Köster,Y. Bernice Chao,Marian Mosior,Amy M. Ford,Patricia Gonzalez-DeWhitt,John E. Hale,De-Shan Li,Yubin Qiu,Christopher C. Fraser,Derek D. Yang,Josef G. Heuer,S. Richard Jaskunas,Patrick I. Eacho +12 more
TL;DR: Angptl3 and Angptl4 function to regulate circulating triglyceride levels during different nutritional states and therefore play a role in lipid metabolism during feeding/fasting through differential inhibition of LPL.
Journal ArticleDOI
Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319
Alexei Kharitonenkov,John Michael Beals,Radmila Micanovic,Beth A. Strifler,Radhakrishnan Rathnachalam,Victor J. Wroblewski,Shun Li,Anja Koester,Amy M. Ford,Tamer Coskun,James D. Dunbar,Christine C. Cheng,Christopher C. Frye,Bumol Thomas Frank,David E. Moller +14 more
TL;DR: LY2405319 exhibited all the biopharmaceutical and biological properties required for initiation of a clinical program designed to test the hypothesis that administration of exogenous FGF21 would result in effects on disease-related metabolic parameters in humans.
Journal ArticleDOI
Cecal ligation and puncture with total parenteral nutrition: a clinically relevant model of the metabolic, hormonal, and inflammatory dysfunction associated with critical illness.
Josef G. Heuer,Dianna L. Bailey,Ganesh R. Sharma,Tonghai Zhang,Chunjin Ding,Amy M. Ford,Eddie J. Stephens,Kimberly C. Holmes,Renee L. Grubbs,Kelly A. Fynboe,Yun Fei Chen,Joseph A. Jakubowski +11 more
TL;DR: The results indicate that addition of TPN to CLP provides a clinically relevant animal model of critical illness with associated hyperglycemia that may provide utility for the testing of glucoregulatory and other therapeutic modalities.