Ana Hernández-Plaza

TL;DR: eggNOG as discussed by the authors is a public database of orthology relationships, gene evolutionary histories and functional annotations, with a major update of the underlying genome sets, which have been expanded to 4445 representative bacteria and 168 archaea derived from 25 038 genomes.

TL;DR: For example, EggNOG-mapper v2 as mentioned in this paper is a tool for functional annotation based on precomputed orthology assignments, optimized for vast (meta)genomic data sets.

TL;DR: For example, EggNOG-mapper v2 as mentioned in this paper is a tool for functional annotation based on precomputed orthology assignments, optimized for vast (meta)genomic data sets.

TL;DR: The data indicate a link between neuroid and immune functions in sponges, and suggest that a primordial neuro-immune system cleared intruders and controlled ciliary beating for feeding, and uncover ‘presynaptic’ genes in an amoeboid-neuroid cell type, and ‘postsynaptic' genes in digestive choanocytes, suggesting asymmetric and targeted communication.

TL;DR: This paper used whole-body single-cell RNA sequencing in a sponge, an animal without nervous system and musculature, to identify the evolutionary origin of metazoan cell types such as neurons and muscles.