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Ana J. García-Sáez
Researcher at University of Cologne
Publications - 131
Citations - 10109
Ana J. García-Sáez is an academic researcher from University of Cologne. The author has contributed to research in topics: Membrane & Vesicle. The author has an hindex of 37, co-authored 115 publications receiving 6333 citations. Previous affiliations of Ana J. García-Sáez include Max Planck Society & University of Tübingen.
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Book ChapterDOI
Role of membrane lipids for the activity of pore forming peptides and proteins
Gustavo Fuertes,Diana Gimenez,Santi Esteban-Martín,Ana J. García-Sáez,Orlando Sánchez,Jesús Salgado +5 more
TL;DR: Active peptides and proteins can thus be considered inducers or enhancers of pores which increase their probability and lifetime by modifying the thermodynamic membrane balance.
Journal ArticleDOI
Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore‐forming activity
Haydee Mesa-Galloso,Karelia H. Delgado-Magnero,Sheila Cabezas,Aracelys López-Castilla,Jorge E. Hernández-González,Lohans Pedrera,Carlos Alvarez,D. Peter Tieleman,Ana J. García-Sáez,María E. Lanio,Uris Ros,Pedro A. Valiente +11 more
TL;DR: It is demonstrated that disrupting the key hydrophobic interaction between V60 and F163 in the oligomerization interface of FraC, equinatoxin II (EqtII), and sticholysin II (StII) impairs the pore formation activity of these proteins.
Journal ArticleDOI
Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.
Olivier Jalmar,Liberty François-Moutal,Ana J. García-Sáez,Ana J. García-Sáez,Mark Edward Perry,Thierry Granjon,Francois Gonzalvez,Eyal Gottlieb,Jesus Ayala-Sanmartin,Beate Klösgen,Petra Schwille,Patrice X. Petit +11 more
TL;DR: Light is shed on the active functional role of cardiolipin, bridging the gap between death receptors and mitochondria, for caspase-8 activation and Bid binding and cleavage in type II cells.
Journal ArticleDOI
Atomic force microscopy imaging and force spectroscopy of supported lipid bilayers
TL;DR: This protocol demonstrates how to prepare supported bilayers and characterize their structure and mechanical properties using AFM, which play an important role in cellular processes such as maintaining cell hemostasis from environmental stress and stabilizing protein complexes.
Journal ArticleDOI
Membranes in motion: mitochondrial dynamics and their role in apoptosis.
TL;DR: The key components of mitochondrial dynamics have been identified and an interplay between the proteins of the mitochondrial fission/fusion machinery and the Bcl-2 proteins, essential mediators in apoptosis, has been described.