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Ana J. García-Sáez

Researcher at University of Cologne

Publications -  131
Citations -  10109

Ana J. García-Sáez is an academic researcher from University of Cologne. The author has contributed to research in topics: Membrane & Vesicle. The author has an hindex of 37, co-authored 115 publications receiving 6333 citations. Previous affiliations of Ana J. García-Sáez include Max Planck Society & University of Tübingen.

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Journal ArticleDOI

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium.

Uris Ros, +7 more
- 04 Apr 2017 - 
TL;DR: It is found that early increase in cytosolic calcium in TNF-induced necroptosis is mediated by treatment with a Smac mimetic via the TNF/RIP1/TAK1 survival pathway and requires the RIP1/RIP3/MLKL core.
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Fluorescence correlation spectroscopy for the study of membrane dynamics and protein/lipid interactions.

Ana J. García-Sáez, +1 more
- 01 Oct 2008 - 
TL;DR: The theoretical basis of FCS is described and some practical implications for its application in membrane studies are discussed, including sources of potential artifacts, such as membrane undulations, positioning of the detection volume, and photobleaching.
Journal ArticleDOI

Pore formation in regulated cell death.

Hector Flores-Romero, +2 more
- 01 Dec 2020 - 
TL;DR: This work compares and contrast how BAX/BAK, Gasdermins, and MLKL alter membrane permeability from a structural and biophysical perspective and discusses the general principles of membrane permeabilization in the execution of regulated cell death.
Journal ArticleDOI

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics.

Lohans Pedrera, +9 more
- 01 May 2021 - 
TL;DR: These findings with ferroptosis provide a unifying concept that sustained increase of cytosolic Ca2+ prior to plasma membrane rupture is a common feature of regulated types of necrosis and position ESCRT-III activation as a general protective mechanism in these lytic cell death pathways.
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Pores Formed by Baxα5 Relax to a Smaller Size and Keep at Equilibrium

Gustavo Fuertes, +6 more
- 03 Nov 2010 - 
TL;DR: Investigating the pore activity of the α5 fragment from the proapoptotic protein Bax (Baxα5) before and after equilibrium of peptide/vesicle complexes results in stable pores on single giant unilamellar vesicles (GUVs), and stable pores were also detected in GUVs made in the presence of Bax α5.