Ana J. García-Sáez

TL;DR: It is pointed out that although the plasma membrane is the common target in regulated necrosis, different mechanisms of permeabilization have emerged depending on the cell death form, and this diverse repertoire of mechanisms leading to membrane permeabilized contributes to define the specific inflammatory and immunological outcome of each type ofregulated necrosis.

TL;DR: The results suggest that PXA is a mitochondrial toxin with a novel mode of action that might prove a useful tool for the study of mitochondrial ion homoeostasis and membrane dynamics.

TL;DR: It is shown how the combination of spectroscopically distinguishable nitroxide and gadolinium spin labels and Double Electron-Electron Resonance can help to gain new insights into the quaternary structure of active, membrane-embedded Bax oligomers.

TL;DR: The findings suggest an active role for mitochondrial membrane lipids, particularly CL, in binding active caspase-8 and providing a docking site for Bid-FL, which was previously only poorly documented and substantially underestimated.

TL;DR: Antibody partitioning into lipid bilayers required the specific recognition of membrane‐inserted epitope, indicating that 2F5 was unable to directly react with GUV phospholipids, even under fluid phase segregation conditions.