A
Anastasia Georgiadi
Researcher at Wageningen University and Research Centre
Publications - 22
Citations - 1598
Anastasia Georgiadi is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Adipose tissue & Inflammation. The author has an hindex of 14, co-authored 21 publications receiving 1302 citations. Previous affiliations of Anastasia Georgiadi include Karolinska Institutet & Heidelberg University.
Papers
More filters
Journal ArticleDOI
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
Lee D. Roberts,Pontus Boström,Pontus Boström,John F. O'Sullivan,Robert T. Schinzel,Gregory D. Lewis,Gregory D. Lewis,Andre Dejam,Youn-Kyoung Lee,Melinda J. Palma,Sondra Calhoun,Anastasia Georgiadi,Ming-Huei Chen,Ming-Huei Chen,Vasan S. Ramachandran,Vasan S. Ramachandran,Martin G. Larson,Martin G. Larson,Claude Bouchard,Tuomo Rankinen,Amanda Souza,Clary B. Clish,Thomas J. Wang,Thomas J. Wang,Jennifer L. Estall,Alexander A. Soukas,Chad A. Cowan,Bruce M. Spiegelman,Robert E. Gerszten,Robert E. Gerszten +29 more
TL;DR: In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors, and β-aminoisobutyric acid (BAIBA) may contribute to exercise-induced protection from metabolic diseases.
Journal ArticleDOI
Mechanisms of Gene Regulation by Fatty Acids
TL;DR: This work focuses on fatty acid sensing via regulation of gene transcription and addresses the role of peroxisome proliferator-activated receptors, sterol regulatory element binding protein 1, Toll-like receptor 4, G protein-coupled receptors, and other putative mediators.
Journal ArticleDOI
Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages
Laeticia Lichtenstein,Frits Mattijssen,Nicole de Wit,Anastasia Georgiadi,Guido J. E. J. Hooiveld,Roelof van der Meer,Yin He,Ling Qi,Anja Köster,Jouke T. Tamsma,Nguan Soon Tan,Michael Müller,Sander Kersten,Sander Kersten +13 more
TL;DR: Induction of macrophage Angptl4 by fatty acids is part of a mechanism that serves to reduce postprandial lipid uptake from chyle into MLN-resident macrophages by inhibiting triglyceride hydrolysis, thereby preventing Macrophage activation and foam cell formation and protecting against progressive, uncontrolled saturated fat-induced inflammation.
Journal ArticleDOI
Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress.
Anastasia Georgiadi,Laeticia Lichtenstein,Tatjana Degenhardt,Mark V. Boekschoten,Marc van Bilsen,Béatrice Desvergne,Michael Müller,Sander Kersten +7 more
TL;DR: Stimulation of cardiac Angptl4 gene expression by dietary fatty acids and via PPAR&bgr;/&dgr; is part of a feedback mechanism aimed at protecting the heart against lipid overload and consequently fatty acid–induced oxidative stress.
Journal ArticleDOI
Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development
Anastasia Georgiadi,Yanan Wang,Rinke Stienstra,Nathanja Tjeerdema,Aafke W. F. Janssen,Anton F. H. Stalenhoef,J. Adam van der Vliet,Albert de Roos,Jouke T. Tamsma,Johannes W. A. Smit,Nguan Soon Tan,Michael Müller,Patrick C.N. Rensen,Sander Kersten +13 more
TL;DR: Stimulation of Angptl4 in macrophages by oxidized low-density lipoprotein may protect against lipid overload and suppresses foam cell formation to reduce atherosclerosis development.