A
André H. Juffer
Researcher at University of Oulu
Publications - 44
Citations - 1373
André H. Juffer is an academic researcher from University of Oulu. The author has contributed to research in topics: Binding site & Active site. The author has an hindex of 19, co-authored 44 publications receiving 1195 citations.
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Journal ArticleDOI
Proteome-wide Analysis of Lysine Acetylation Suggests its Broad Regulatory Scope in Saccharomyces cerevisiae
Peter Henriksen,Sebastian A. Wagner,Brian T. Weinert,Satyan Sharma,Giedrė Bačinskaja,Michael Rehman,André H. Juffer,Tobias C. Walther,Michael Lisby,Chunaram Choudhary +9 more
TL;DR: The data provides the first global survey of acetylation in budding yeast, and suggests a wide-ranging regulatory scope of this modification, which may serve as an important resource for the functional analysis of lysines in eukaryotes.
Journal ArticleDOI
A conserved arginine plays a role in the catalytic cycle of the protein disulphide isomerases.
Anna Kaisa A.K. Lappi,Marc F. Lensink,Heli I. Alanen,Kirsi E.H. Salo,Mario M. Lobell,André H. Juffer,Lloyd W. Ruddock +6 more
TL;DR: The identification of a conserved arginine residue, located in the loop between beta5 and alpha4 of the catalytic domains of the human protein disulphide isomerase (PDI) family, which is critical for the catalysttic function of PDI, ERp57, ER p72 and P5, specifically for reoxidation is reported.
Journal ArticleDOI
Expanding the lysyl hydroxylase toolbox: new insights into the localization and activities of lysyl hydroxylase 3 (LH3).
Raili Myllylä,Chunguang Wang,Jari Heikkinen,André H. Juffer,Outi Lampela,Maija Risteli,Heli Ruotsalainen,Antti M. Salo,Laura Sipilä +8 more
TL;DR: It is shown that growth cone migration depends critically on the LH3 glycosyltransferase domain, but, unlike the other isoforms, LH3 is also found in the extracellular space in some tissues, suggesting that it may have a role in matrix remodeling.
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Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development
Outi M. H. Salo-Ahen,Ida Alanko,Rajendra Bhadane,Alexandre M. J. J. Bonvin,Rodrigo V. Honorato,Shakhawath Hossain,André H. Juffer,Aleksei Kabedev,Maija Lahtela-Kakkonen,Anders S. Larsen,Eveline Lescrinier,Parthiban Marimuthu,Muhammad Usman Mirza,Ghulam Mustafa,Ariane Nunes-Alves,Ariane Nunes-Alves,Tatu Pantsar,Tatu Pantsar,Atefeh Saadabadi,Kalaimathy Singaravelu,Michiel Vanmeert +20 more
TL;DR: A broad overview of the current application possibilities of MD in drug discovery and pharmaceutical development is given, including how MD can be used in studying the crystalline and amorphous solids, the stability ofAmorphous drug or drug-polymer formulations, and drug solubility.
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A class V chitinase from Arabidopsis thaliana : gene responses, enzymatic properties, and crystallographic analysis
Takayuki Ohnuma,Tomoyuki Numata,Takuo Osawa,Mamiko Mizuhara,Outi Lampela,André H. Juffer,Karen Skriver,Tamo Fukamizo +7 more
TL;DR: All of the structural and functional properties of AtChiC are quite similar to those obtained for NtChiV, and seem to be common to class V chitinases from higher plants.