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Andrea Brinkmann
Researcher at Goethe University Frankfurt
Publications - 4
Citations - 1351
Andrea Brinkmann is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Chronic granulomatous disease & NKG2D. The author has an hindex of 3, co-authored 4 publications receiving 1295 citations.
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Journal ArticleDOI
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Marion Ott,Manfred Schmidt,Kerstin Schwarzwaelder,Stefan Stein,Ulrich Siler,Ulrike Koehl,Hanno Glimm,K. Kühlcke,Andrea Schilz,Hana Kunkel,Sonja Naundorf,Andrea Brinkmann,Annette Deichmann,Marlene Fischer,Claudia R. Ball,Ingo H. Pilz,Cynthia E. Dunbar,Yang Du,Nancy A. Jenkins,Neal G. Copeland,Ursula Lüthi,Moustapha Hassan,Adrian J. Thrasher,Dieter Hoelzer,Christof von Kalle,Reinhard Seger,Manuel Grez +26 more
TL;DR: The results suggest that gene therapy in combination with bone marrow conditioning can be successfully used to treat inherited diseases affecting the myeloid compartment such as CGD.
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IL-2-driven regulation of NK cell receptors with regard to the distribution of CD16+ and CD16- subpopulations and in vivo influence after haploidentical NK cell infusion.
Sabine Huenecke,Stefanie Zimmermann,Stephan Kloess,Ruth Esser,Andrea Brinkmann,Lars Tramsen,Melanie Koenig,Stephanie Erben,Christian Seidl,Torsten Tonn,Angelika Eggert,Alexander Schramm,Peter Bader,Thomas Klingebiel,Thomas Lehrnbecher,Jakob Passweg,Jan Soerensen,Dirk Schwabe,Ulrike Koehl +18 more
TL;DR: The data indicate that IL-2 stimulation increases the expression of activating receptors and emphasizes mechanisms beside KIR/human leukocyte antigen and the results suggest that the expansion period of purified NK cells has to be individualized to optimize NK cell immunotherapy.
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IL-2-activated haploidentical NK cells restore NKG2D-mediated NK-cell cytotoxicity in neuroblastoma patients by scavenging of plasma MICA.
Stephan Kloess,Sabine Huenecke,Daniel Piechulek,Ruth Esser,Joachim Koch,Claudia Brehm,Jan Soerensen,Tanja Gardlowski,Andrea Brinkmann,Peter Bader,Jakob Passweg,Thomas Klingebiel,Dirk Schwabe,Ulrike Koehl +13 more
TL;DR: The data suggest that the provided excess of NKG2D leads to clearance of sMICA and preserves cytotoxicity of dNK cells via non‐occupied NKG 2D, which identifies this tumor immune escape mechanism as a target to improve immunotherapy of neuroblastoma and presumably other tumors.
Journal ArticleDOI
Long-Term Follow-Up of Patients Treated by Gene Therapy for X-Linked Chronic Granulomatous Disease.
Marion Ott,Manuel Grez,Stefan Stein,Ulrich Siler,Ulrike Koehl,Klaus Kuehlcke,Manfred Schmidt,Andrea Schilz,Hana Kunkel,Sonja Naundorf,Andrea Brinkmann,Moustapha Hassan,Christof von Kalle,Adrian Trasher,Reinhard Seger,Dieter Hoelzer +15 more