K
K. Kühlcke
Researcher at European Institute
Publications - 4
Citations - 1325
K. Kühlcke is an academic researcher from European Institute. The author has contributed to research in topics: Haematopoiesis & Genetic enhancement. The author has an hindex of 3, co-authored 4 publications receiving 1231 citations.
Papers
More filters
Journal ArticleDOI
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Marion Ott,Manfred Schmidt,Kerstin Schwarzwaelder,Stefan Stein,Ulrich Siler,Ulrike Koehl,Hanno Glimm,K. Kühlcke,Andrea Schilz,Hana Kunkel,Sonja Naundorf,Andrea Brinkmann,Annette Deichmann,Marlene Fischer,Claudia R. Ball,Ingo H. Pilz,Cynthia E. Dunbar,Yang Du,Nancy A. Jenkins,Neal G. Copeland,Ursula Lüthi,Moustapha Hassan,Adrian J. Thrasher,Dieter Hoelzer,Christof von Kalle,Reinhard Seger,Manuel Grez +26 more
TL;DR: The results suggest that gene therapy in combination with bone marrow conditioning can be successfully used to treat inherited diseases affecting the myeloid compartment such as CGD.
Journal ArticleDOI
Gene therapy for Wiskott-Aldrich syndrome-long - Term efficacy and genotoxicity (Science Translational Medicine)
Christian Braun,Kaan Boztug,Anna Paruzynski,Maximilian Witzel,Adrian Schwarzer,Michael Rothe,Ute Modlich,Rita Beier,Gudrun Göhring,Doris Steinemann,Raffaele Fronza,Claudia R. Ball,Reinhard Haemmerle,S. Naundorf,K. Kühlcke,Martina Rose,Chris Fraser,Liesl Mathias,Rudolf Ferrari,Miguel R. Abboud,Waleed Al-Herz,Irina Kondratenko,László Maródi,Hanno Glimm,Brigitte Schlegelberger,Axel Schambach,Michael H. Albert,Manfred G. Schmidt,C. Von Kalle,Christian Klein +29 more
Journal ArticleDOI
Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus
Axel Schambach,Bernhard Schiedlmeier,K. Kühlcke,Monique M A Verstegen,Monique M A Verstegen,Geoffrey P. Margison,Zhixiong Li,Kenji Kamino,Jens Bohne,Alexander Alexandrov,Felix Hermann,D von Laer,Christopher Baum,Christopher Baum +13 more
TL;DR: This work tested whether HSCs and their progeny can be modified to express therapeutic levels of M87o, a gammaretroviral vector encoding an artificial transmembrane molecule that blocks fusion-mediated uptake of HIV.
Journal ArticleDOI
Cell and virus genetics at the roots of gene therapy, retrovirology, and hematopoietic stem cell biology: Wolfram Ostertag (1937-2010).
Carol Stocking,Manuel Grez,Boris Fehse,von Laer D,Katsuhiko Itoh,Prassolov,Nowock J,K. Kühlcke,Ursula Just,Schröder T,Hannes Klump,Bernhard Schiedlmeier,Elke Grassman,Johann Meyer,Zhixiong Li,Axel Schambach,Ute Modlich,Olga S. Kustikova,Melanie Galla,Juergen Bode,Axel R. Zander,Christopher Baum +21 more