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Andreas Junker
Researcher at Max Planck Society
Publications - 13
Citations - 1192
Andreas Junker is an academic researcher from Max Planck Society. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 7, co-authored 7 publications receiving 1082 citations.
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Journal ArticleDOI
MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
Andreas Junker,Markus Krumbholz,S. Eisele,Hema Mohan,Florian Augstein,Robert Bittner,Hans Lassmann,Hartmut Wekerle,Reinhard Hohlfeld,Edgar Meinl +9 more
TL;DR: It is suggested that microRNA dysregulated in multiple sclerosis lesions reduce CD47 in brain resident cells, releasing macrophages from inhibitory control, thereby promoting phagocytosis of myelin and have broad implications for microRNA-regulated macrophage activation in inflammatory diseases.
Journal ArticleDOI
Multiple sclerosis: T-cell receptor expression in distinct brain regions.
Andreas Junker,Jana Ivanidze,Joachim Malotka,Ingrid Eiglmeier,Hans Lassmann,Hartmut Wekerle,Edgar Meinl,Reinhard Hohlfeld,Klaus Dornmair +8 more
TL;DR: P pervasive T-cell clones exist in distinct regions of MS brain, and these clones are 'private' (unique) to individual patients, supporting the pathogenic relevance of this T- cell subset.
Journal ArticleDOI
Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells
Hema Mohan,Markus Krumbholz,Rakhi Sharma,S. Eisele,Andreas Junker,Michael Sixt,Jia Newcombe,Hartmut Wekerle,Reinhard Hohlfeld,Hans Lassmann,Edgar Meinl +10 more
TL;DR: Induced fibrillar collagens may contribute to limiting enlargement of MS lesions by inhibiting the production of CCL2 by monocytes and proteins forming a perivascular fibrosis were identified.
Journal ArticleDOI
CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions.
Markus Krumbholz,Diethilde Theil,F. Steinmeyer,Sabine Cepok,Bernhard Hemmer,M. Hofbauer,Cinthia Farina,Tobias Derfuss,Andreas Junker,Thomas Arzberger,I. Sinicina,Caroline Hartle,Jia Newcombe,Reinhard Hohlfeld,Edgar Meinl +14 more
TL;DR: This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients.
Journal ArticleDOI
The emerging role of microRNAs in multiple sclerosis.
TL;DR: The possible contribution of miRNAs to MS pathogenesis is discussed and an improved understanding of this contribution should help to identify novel therapeutic targets and biomarkers for this disease.