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Edgar Meinl
Researcher at Ludwig Maximilian University of Munich
Publications - 166
Citations - 14608
Edgar Meinl is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Multiple sclerosis & T cell. The author has an hindex of 61, co-authored 153 publications receiving 12883 citations. Previous affiliations of Edgar Meinl include University of Erlangen-Nuremberg & Hoffmann-La Roche.
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Journal ArticleDOI
Astrocytes are active players in cerebral innate immunity
TL;DR: Evidence is emerging that the most abundant glial cell population of the CNS, the astrocyte, participates in the local innate immune response triggered by a variety of insults.
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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
Ping Shen,Toralf Roch,Vicky Lampropoulou,Richard A. O’Connor,Ulrik Stervbo,Ellen Hilgenberg,Stefanie Ries,Van Duc Dang,Yarúa Jaimes,Capucine Daridon,Capucine Daridon,Rui Li,Luc Jouneau,Pierre Boudinot,Siska Wilantri,Imme Sakwa,Yusei Miyazaki,Melanie D. Leech,Rhoanne C. McPherson,Stefan Wirtz,Markus F. Neurath,Kai Hoehlig,Edgar Meinl,Andreas Grützkau,Joachim R. Grün,Katharina Horn,Anja A. Kühl,Thomas Dörner,Thomas Dörner,Amit Bar-Or,Stefan H. E. Kaufmann,Stephen M. Anderton,Simon Fillatreau +32 more
TL;DR: The increased immunity found in mice lacking IL-35 production by B cells was associated with a higher activation of macrophages and inflammatory T cells, as well as an increased function of B cells as antigen-presenting cells (APCs).
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Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
Frédéric Altare,Anne Durandy,David A. Lammas,J.F. Emile,S Lamhamedi,Françoise Le Deist,Pam Drysdale,Emmanuelle Jouanguy,Rainer Doffinger,Françoise Bernaudin,Olle Jeppsson,Jared Gollob,Edgar Meinl,Antony W. Segal,Alain Fischer,Dinakantha S. Kumararatne,Jean-Laurent Casanova +16 more
TL;DR: Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections, and mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells.
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MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
Andreas Junker,Markus Krumbholz,S. Eisele,Hema Mohan,Florian Augstein,Robert Bittner,Hans Lassmann,Hartmut Wekerle,Reinhard Hohlfeld,Edgar Meinl +9 more
TL;DR: It is suggested that microRNA dysregulated in multiple sclerosis lesions reduce CD47 in brain resident cells, releasing macrophages from inhibitory control, thereby promoting phagocytosis of myelin and have broad implications for microRNA-regulated macrophage activation in inflammatory diseases.
Journal ArticleDOI
Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment.
Markus Krumbholz,Diethilde Theil,Sabine Cepok,Bernhard Hemmer,Pia Kivisäkk,Richard M. Ransohoff,Monika Hofbauer,Cinthia Farina,Tobias Derfuss,Caroline Hartle,Jia Newcombe,Reinhard Hohlfeld,Edgar Meinl +12 more
TL;DR: The strong linkage of CXCL13 to immune cells and immunoglobulin levels in CSF suggests that this is one of the factors that attract and maintain B and T cells in inflamed CNS lesions.