D
Diethilde Theil
Researcher at Max Planck Society
Publications - 11
Citations - 1974
Diethilde Theil is an academic researcher from Max Planck Society. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 8, co-authored 9 publications receiving 1802 citations. Previous affiliations of Diethilde Theil include University College London.
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Journal ArticleDOI
Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment.
Markus Krumbholz,Diethilde Theil,Sabine Cepok,Bernhard Hemmer,Pia Kivisäkk,Richard M. Ransohoff,Monika Hofbauer,Cinthia Farina,Tobias Derfuss,Caroline Hartle,Jia Newcombe,Reinhard Hohlfeld,Edgar Meinl +12 more
TL;DR: The strong linkage of CXCL13 to immune cells and immunoglobulin levels in CSF suggests that this is one of the factors that attract and maintain B and T cells in inflamed CNS lesions.
Journal ArticleDOI
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
Markus Krumbholz,Diethilde Theil,Tobias Derfuss,Andreas Rosenwald,Frank Schrader,Camelia-Maria Monoranu,Susan L. Kalled,Donna M. Hess,Barbara Serafini,Francesca Aloisi,Hartmut Wekerle,Reinhard Hohlfeld,Edgar Meinl +12 more
TL;DR: Astrocytes is identified as a nonimmune source of B cell–activating factor of the tumor necrosis factor family and CNS-produced BAFF may support B cell survival in inflammatory diseases and primary B cell lymphoma.
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Methylprednisolone, Valacyclovir, or the Combination for Vestibular Neuritis
Michael Strupp,V. C. Zingler,Viktor Arbusow,Daniel Niklas,Klaus Peter Maag,Marianne Dieterich,Sandra Bense,Diethilde Theil,Klaus Jahn,Thomas Brandt +9 more
TL;DR: Methylprednisolone significantly improves the recovery of peripheral vestibular function in patients with Vestibular neuritis, whereas valacyclovir does not, and the combination of methylpredisonsolone and valacyClovir was not superior to corticosteroid monotherapy.
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Latent Herpesvirus Infection in Human Trigeminal Ganglia Causes Chronic Immune Response
Diethilde Theil,Tobias Derfuss,Igor Paripovic,Simone Herberger,Edgar Meinl,Olaf Schueler,Michael Strupp,Viktor Arbusow,Thomas Brandt +8 more
TL;DR: The persisting lymphocytic cell infiltration and the elevated CD8 and cytokine/chemokine expression in the TGs demonstrate for the first time that latent herpesviral infection in humans is accompanied by a chronic inflammatory process at an immunoprivileged site but without any neuronal destruction.
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CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions.
Markus Krumbholz,Diethilde Theil,F. Steinmeyer,Sabine Cepok,Bernhard Hemmer,M. Hofbauer,Cinthia Farina,Tobias Derfuss,Andreas Junker,Thomas Arzberger,I. Sinicina,Caroline Hartle,Jia Newcombe,Reinhard Hohlfeld,Edgar Meinl +14 more
TL;DR: This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients.