Journal ArticleDOI
CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions.
Markus Krumbholz,Diethilde Theil,F. Steinmeyer,Sabine Cepok,Bernhard Hemmer,M. Hofbauer,Cinthia Farina,Tobias Derfuss,Andreas Junker,Thomas Arzberger,I. Sinicina,Caroline Hartle,Jia Newcombe,Reinhard Hohlfeld,Edgar Meinl +14 more
TLDR
This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients.About:
This article is published in Journal of Neuroimmunology.The article was published on 2007-10-01. It has received 120 citations till now. The article focuses on the topics: Multiple sclerosis & Immunosurveillance.read more
Citations
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Journal ArticleDOI
Capture, crawl, cross: the T cell code to breach the blood-brain barriers
TL;DR: With a focus on multiple sclerosis (MS) and its animal models, this review summarizes the distinct molecular mechanisms required for immune cell migration across the different CNS barriers.
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Trafficking of immune cells in the central nervous system.
TL;DR: In this review, several recent advances are highlighted that provide new insights into the processes that regulate leukocyte access to, and movement within, the brain.
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B cells and antibodies in multiple sclerosis pathogenesis and therapy
TL;DR: Key features of B-cell biology, the role of B cells and antibodies in CNS inflammation, and current attempts to identify the targets of pathogenic antibodies in MS are summarized.
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The blood-brain barrier, chemokines and multiple sclerosis
TL;DR: This review focuses on the differential display of chemokines along endothelial surfaces and how they impact leukocyte extravasation into parenchymal tissues, especially within the CNS.
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Changes in B- and T-Lymphocyte and Chemokine Levels With Rituximab Treatment in Multiple Sclerosis
Laura Piccio,Robert T. Naismith,Kathryn Trinkaus,Robyn S. Klein,Becky J. Parks,Jeri A. Lyons,Anne H. Cross +6 more
TL;DR: In subjects with multiple sclerosis, B cells are critical for T-cell trafficking into the central nervous system and may alter the process by influencing chemokine production within the central nerve system.
References
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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The Many Roles of Chemokines and Chemokine Receptors in Inflammation
TL;DR: The properties of chemokines and their receptors are discussed and the roles of these chemoattractants in selected clinical disorders are highlighted.
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Immunology of multiple sclerosis
Mireia Sospedra,Roland Martin +1 more
TL;DR: In the early stages of MS, the activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype are a crucial events in the initial steps, and these cells are probably also important players in the long-term evolution of the disease.
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Multiple Sclerosis — The Plaque and Its Pathogenesis
TL;DR: This review focuses on the current knowledge of the pathogenesis of the inflammatory and neurodegenerative elements of the multiple sclerosis plaque.
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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.
TL;DR: Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived and are fully competent to present antigen to lymphocytes in an appropriately restricted manner.