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Andreas Larsson
Researcher at Nanyang Technological University
Publications - 130
Citations - 2085
Andreas Larsson is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: New product development & Wireless sensor network. The author has an hindex of 23, co-authored 121 publications receiving 1796 citations. Previous affiliations of Andreas Larsson include Karolinska Institutet & Chalmers University of Technology.
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Journal ArticleDOI
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria
Jerome S. Pinkner,Han Remaut,Floris Buelens,Eric L. Miller,Veronica Åberg,Nils Pemberton,Mattias Hedenström,Andreas Larsson,Patrick C. Seed,Gabriel Waksman,Scott J. Hultgren,Fredrik Almqvist +11 more
TL;DR: These pilicides target key virulence Factors in pathogenic bacteria and represent a promising proof of concept for developing drugs that function by targeting virulence factors.
Journal ArticleDOI
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay
Jerzy Michal Dziekan,Han Yu,Dan Chen,Lingyun Dai,Grennady Wirjanata,Andreas Larsson,Nayana Prabhu,Radoslaw M. Sobota,Zbynek Bozdech,Pär Nordlund,Pär Nordlund,Pär Nordlund +11 more
TL;DR: The cellular thermal shift assay coupled with mass spectrometry (MS-CETSA) for drug target identification in Plasmodium falciparum constitutes a promising strategy to elucidate the MoAs of existing and candidate antimalarial drugs.
Journal ArticleDOI
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Helena Almqvist,Hanna Axelsson,Rozbeh Jafari,Rozbeh Jafari,Chen Dan,André Mateus,Martin Haraldsson,Andreas Larsson,Daniel Martinez Molina,Per Artursson,Per Artursson,Thomas Lundbäck,Pär Nordlund,Pär Nordlund,Pär Nordlund +14 more
TL;DR: The first compound library screen based on biophysical measurements of intracellular target binding, exemplified by human thymidylate synthase, is reported, establishing efficient means to associate drug uptake and activation with target binding during drug discovery.
Proceedings ArticleDOI
Making sense of collaboration: the challenge of thinking together in global design teams
TL;DR: Observations of how a team of designers negotiate shared understanding in the collaborative design of Virtual Pedals for Volvo Car Corporation are presented, suggesting that the addition of shared 'objects to think with' in distributed design environments could greatly facilitate global design teams in their collaborative process of 'thinking together apart'.
Journal ArticleDOI
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.
Mayumi Kitagawa,Pei-Ju Liao,Kyunghee Lee,Jasmine Wong,See Cheng Shang,Noriaki Minami,Oltea Sampetrean,Hideyuki Saya,Dai Lingyun,Nayana Prabhu,Go Ka Diam,Radoslaw M. Sobota,Andreas Larsson,Pär Nordlund,Pär Nordlund,Pär Nordlund,Frank McCormick,Sujoy Ghosh,Sujoy Ghosh,David M. Epstein,Brian W. Dymock,Sang Hyun Lee +21 more
TL;DR: A molecule a131 with dual-inhibitory properties is identified, which targets PI5P4K and mitosis, and it is involved in Ras/Raf/MEK/ERK and PI3K/Akt/mTOR crosstalk, thereby causing reversible growth arrest in normal cells and cell death of tumor cells.