Han Remaut

TL;DR: These pilicides target key virulence Factors in pathogenic bacteria and represent a promising proof of concept for developing drugs that function by targeting virulence factors.

TL;DR: Structural, functional and electrophysiological analyses imply that Escherichia coli CsgG is an ungated, non-selective protein secretion channel that is expected to employ a diffusion-based, entropy-driven transport mechanism.

TL;DR: The structural basis for pilus fiber assembly and secretion performed by the outer membrane assembly platform--the usher--is revealed by the crystal structure of the translocation domain of the P pilus usher PapC and single particle cryo-electron microscopy imaging of the FimD usher bound to a translocating type 1 pilus assembly intermediate.

TL;DR: Bacterial pathogens utilize the chaperone-usher pathway to assemble extracellular multi-subunit fibers essential for virulence, which releases folding energy that drives subunit incorporation into the fiber, which grows through a pore formed by the outer-membrane usher.

TL;DR: It is shown that F17-like and type 1 pili promote intestinal colonization and show distinct binding to epithelial cells distributed along colonic crypts, and targeting FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota.