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Andrew D. Strand
Researcher at Fred Hutchinson Cancer Research Center
Publications - 39
Citations - 6284
Andrew D. Strand is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 27, co-authored 39 publications receiving 5892 citations. Previous affiliations of Andrew D. Strand include University of Washington.
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Journal ArticleDOI
Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease
Ruth Luthi-Carter,Andrew D. Strand,Nikki L. Peters,Steven M. Solano,Zane R. Hollingsworth,Anil Menon,Ariel S. Frey,Boris S. Spektor,Ellen B. Penney,Gabriele Schilling,Christopher A. Ross,David R. Borchelt,Stephen J. Tapscott,Anne B. Young,Jang Ho J. Cha,James M. Olson +15 more
TL;DR: It is demonstrated that mutant huntingtin directly or indirectly reduces the expression of a distinct set of genes involved in signaling pathways known to be critical to striatal neuron function.
Journal ArticleDOI
Regional and cellular gene expression changes in human Huntington's disease brain.
Angela Hodges,Andrew D. Strand,Aaron K. Aragaki,Alexandre Kuhn,Thierry Sengstag,Gareth Hughes,Linda Anne Elliston,Catherine Hartog,Darlene R. Goldstein,Doris C. V. Thu,Zane R. Hollingsworth,Francois Collin,Beth J. Synek,Peter Holmans,Anne B. Young,Nancy S. Wexler,Mauro Delorenzi,Charles Kooperberg,Sarah J. Augood,Richard L.M. Faull,James M. Olson,Lesley Jones,Ruth Luthi-Carter +22 more
TL;DR: It is concluded that mRNA changes are not attributable to cell loss alone, and data from bona fide HD brains comprise an important reference for hypotheses related to HD and other neurodegenerative diseases.
Journal ArticleDOI
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
Patrick Weydt,Victor V. Pineda,Anne E. Torrence,Randell T. Libby,Terrence F. Satterfield,Eduardo R. Lazarowski,Merle L. Gilbert,Gregory J. Morton,Theodor K. Bammler,Andrew D. Strand,Libin Cui,Richard P. Beyer,Courtney N. Easley,Annette C. Smith,Dimitri Krainc,Serge Luquet,Ian R. Sweet,Michael W. Schwartz,Albert R. La Spada +18 more
TL;DR: Reduced expression of PGC-1alpha target genes in HD patient and mouse striatum is document, which may link transcription dysregulation and mitochondrial dysfunction in HD.
Journal ArticleDOI
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Linda S. Kaltenbach,Eliana Romero,Robert R. Becklin,Rakesh Chettier,Russell Bell,Amit Phansalkar,Andrew D. Strand,Cameron Torcassi,Justin Savage,Anthony Hurlburt,Guang Ho Cha,Lubna Ukani,Cindy Lou Chepanoske,Yuejun Zhen,Sudhir Sahasrabudhe,James M. Olson,Cornelia Kurschner,Lisa M. Ellerby,John M. Peltier,Juan Botas,Robert E. Hughes +20 more
TL;DR: It is demonstrated that high-throughput screening for protein interactions combined with genetic validation in a model organism is a powerful approach for identifying novel candidate modifiers of polyglutamine toxicity.
Journal ArticleDOI
Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain
Ruth Luthi-Carter,Sarah A. Hanson,Andrew D. Strand,Donald A. Bergstrom,Wanjoo Chun,Nikki L. Peters,Annette M. Woods,Edmond Chan,Charles Kooperberg,Dimitri Krainc,Anne B. Young,Stephen J. Tapscott,James M. Olson +12 more
TL;DR: It is discovered that skeletal muscle is also a target of polyglutamine-related perturbations in gene expression, showing changes in mRNAs that are dysregulated in brain and also muscle-specific m RNAs.