Andriy Myronovych

TL;DR: It is demonstrated that the therapeutic value of VSG does not result from mechanical restriction imposed by a smaller stomach, rather, VSG is associated with increased circulating bile acids, and associated changes to gut microbial communities, which point to bile acid and FXR signalling as an important molecular underpinning for the beneficial effects of this weight-loss surgery.

TL;DR: The objective was to investigate the role of bile acids in hepatic steatosis reduction after vertical sleeve gastrectomy (VSG) and to establish an experimental protocol for this study.

TL;DR: The ability of alterations in bile acids to recapitulate important metabolic improvements seen after bariatric surgery is shown to be able to be recapitulated by short circuiting the normal enterohepatic bile circulation.

TL;DR: Preclinical results validate duodenal-endoluminal sleeve as a promising therapeutic approach to diabetes and obesity, which offers reversibility, low risk, low invasiveness and triple benefits including fat mass loss, glucose and lipid metabolism improvement which mechanistically may involve increased villus growth in the upper gut.

TL;DR: In this paper, the role of SHP in NASH improvement after vertical sleeve gastrectomy (VSG) and farnesoid-X-receptor (FXR) was tested.