L
Lars O. Tjernberg
Researcher at Karolinska Institutet
Publications - 104
Citations - 8318
Lars O. Tjernberg is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Amyloid & Amyloid precursor protein. The author has an hindex of 35, co-authored 99 publications receiving 7444 citations. Previous affiliations of Lars O. Tjernberg include Karolinska University Hospital.
Papers
More filters
Journal ArticleDOI
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Bengt Winblad,Bengt Winblad,Philippe Amouyel,Sandrine Andrieu,Clive Ballard,Carol Brayne,Henry Brodaty,Angel Cedazo-Minguez,Bruno Dubois,David Edvardsson,David Edvardsson,Howard Feldman,Laura Fratiglioni,Giovanni B. Frisoni,Serge Gauthier,Jean Georges,Caroline Graff,Caroline Graff,Khalid Iqbal,Frank Jessen,Frank Jessen,Gunilla Johansson,Linus Jönsson,Miia Kivipelto,Miia Kivipelto,Martin Knapp,Francesca Mangialasche,René J. F. Melis,Agneta Nordberg,Agneta Nordberg,Marcel G. M. Olde Rikkert,Chengxuan Qiu,Thomas P. Sakmar,Thomas P. Sakmar,Philip Scheltens,Lon S. Schneider,Reisa A. Sperling,Lars O. Tjernberg,Gunhild Waldemar,Anders Wimo,Henrik Zetterberg,Henrik Zetterberg +41 more
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
Journal ArticleDOI
Arrest of beta-amyloid fibril formation by a pentapeptide ligand.
Lars O. Tjernberg,Jan Näslund,Fredrik Lindqvist,Jan Johansson,Anders R. Karlström,Johan Thyberg,Lars Terenius,Christer Nordstedt +7 more
TL;DR: It is shown that peptides incorporating a short Aβ fragment (KLVFF; Aβ) can bind full-length Aβ and prevent its assembly into amyloid fibrils and suggested that residues Aβ serve as a binding sequence during Aβ polymerization and fibril formation.
Journal ArticleDOI
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
W. Haung Yu,Ana Maria Cuervo,Asok Kumar,Corrinne M. Peterhoff,Stephen D. Schmidt,Ju-Hyun Lee,Ju-Hyun Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Marc Mercken,Mark R. Farmery,Lars O. Tjernberg,Ying Jiang,Ying Jiang,Karen Duff,Karen Duff,Yasuo Uchiyama,Jan Näslund,Paul M. Mathews,Paul M. Mathews,Anne M. Cataldo,Ralph A. Nixon,Ralph A. Nixon +22 more
TL;DR: It is shown that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β- amyloidosis.
Journal ArticleDOI
Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.
Jan Näslund,A Schierhorn,U Hellman,Lars Lannfelt,A D Roses,Lars O. Tjernberg,Jerzy Silberring,Sam Gandy,Bengt Winblad,Paul Greengard +9 more
TL;DR: The relative abundance of A beta structural variants present in amyloid from brains of 10 individuals with sporadic AD, 2 individuals with familial AD carrying specific mutations in the Alzheimer isyloid precursor protein gene, and 5 nondemented elderly controls is determined.
Journal ArticleDOI
A Molecular Model of Alzheimer Amyloid β-Peptide Fibril Formation
Lars O. Tjernberg,David J.E. Callaway,Agneta Tjernberg,Solveig Hahne,Christina Lilliehook,Lars Terenius,Johan Thyberg,Christer Nordstedt +7 more
TL;DR: It is proposed that this decapeptide sequence forms the core of Aβ-fibrils, with the hydrophobic C terminus folding over this core, and the identification of this fundamental sequence and the implied molecular model could facilitate the design of potential inhibitors of amyloidogenesis.