Angelo Balestrieri

TL;DR: Sequences within the HCV E1 and E2 envelope genes were analyzed during the acute phase of hepatitis C in 12 patients with different clinical outcomes to indicate that the evolutionary dynamics of theHCV quasispecies during the emergency phase predict whether the infection will resolve or become chronic.

TL;DR: In the present survey of an iodine-deficient community, a progressive increase with age of goiter prevalence, thyroid nodularity, and functional autonomy was observed, twice as high as that reported in iodine-sufficient areas, mainly due to an increased frequency of toxic nodular goiter.

TL;DR: HCV infection may not induce protective immunity, which has implications for vaccine development and is investigated in three polytransfused thalassaemic children.

TL;DR: High doses of interferon alpha-2a significantly improved the long-term clinical outcome and survival of patients with chronic hepatitis D, even though the majority had active cirrhosis before the onset of therapy.

TL;DR: The study of the evolution of the HCV quasispecies provides prognostic information as early as the first 2 weeks after starting therapy and opens perspectives for elucidating the mechanisms of treatment failure in chronic hepatitis C.