M
Mikolaj Ogrodnik
Researcher at Mayo Clinic
Publications - 35
Citations - 6158
Mikolaj Ogrodnik is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Senolytic. The author has an hindex of 20, co-authored 28 publications receiving 3685 citations. Previous affiliations of Mikolaj Ogrodnik include Nencki Institute of Experimental Biology & Hebrew University of Jerusalem.
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Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Targeting cellular senescence prevents age-related bone loss in mice
Joshua N. Farr,Ming Xu,Megan M. Weivoda,David G. Monroe,Daniel G. Fraser,Jennifer L Onken,Brittany A Negley,Jad G Sfeir,Mikolaj Ogrodnik,Christine M Hachfeld,Nathan K. LeBrasseur,Matthew T. Drake,Robert J. Pignolo,Tamar Pirtskhalava,Tamara Tchkonia,Merry Jo Oursler,James L. Kirkland,Sundeep Khosla +17 more
TL;DR: A causal role for senescent cells in bone loss with aging is established, and targeting these cells has both anti-resorptive and anabolic effects on bone, which suggests a novel treatment strategy not only for osteoporosis, but also for multiple age-related comorbidities.
Journal ArticleDOI
Cellular senescence drives age-dependent hepatic steatosis.
Mikolaj Ogrodnik,Satomi Miwa,Tamar Tchkonia,Dina Tiniakos,Dina Tiniakos,Caroline L. Wilson,Albert Lahat,Christopher P. Day,Christopher P. Day,Alastair D. Burt,Alastair D. Burt,Allyson K. Palmer,Quentin M. Anstee,Sushma Nagaraja Grellscheid,Jan H.J. Hoeijmakers,Jan H.J. Hoeijmakers,Sander Barnhoorn,Derek A. Mann,Thomas G. Bird,Wilbert P. Vermeij,James L. Kirkland,João F. Passos,Thomas von Zglinicki,Diana Jurk +23 more
TL;DR: It is demonstrated that cellular senescence drives hepatic Steatosis and elimination of senescent cells may be a novel therapeutic strategy to reduce steatosis.
Journal ArticleDOI
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Carolyn M Roos,Bin Zhang,Allyson K. Palmer,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Tamar Pirtskhalava,Nassir M. Thalji,Michael A Hagler,Diana Jurk,Leslie A. Smith,Grace Casaclang-Verzosa,Yi Zhu,Marissa J. Schafer,Tamara Tchkonia,James L. Kirkland,Jordan D. Miller +15 more
TL;DR: This is the first study to demonstrate that chronic clearance of senescent cells improves established vascular phenotypes associated with aging and chronic hypercholesterolemia, and may be a viable therapeutic intervention to reduce morbidity and mortality from cardiovascular diseases.
Journal ArticleDOI
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu,Tamara Tchkonia,Husheng Ding,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Ellen R. Lubbers,Tamar Pirtskhalava,Thomas A. White,Kurt O. Johnson,Michael B. Stout,Vojtech Mezera,Nino Giorgadze,Michael D. Jensen,Nathan K. LeBrasseur,James L. Kirkland +14 more
TL;DR: It is found that senescent fat progenitor cells accumulate in adipose tissue with aging and acquire a senescence-associated secretory phenotype (SASP), with increased production of proinflammatory cytokines compared with nonsenescent cells.