J
Jeanne Mialet-Perez
Researcher at University of Toulouse
Publications - 49
Citations - 1850
Jeanne Mialet-Perez is an academic researcher from University of Toulouse. The author has contributed to research in topics: Senescence & Receptor. The author has an hindex of 22, co-authored 45 publications receiving 1302 citations. Previous affiliations of Jeanne Mialet-Perez include Paul Sabatier University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Rhys Anderson,Anthony B. Lagnado,Damien Maggiorani,Anna Walaszczyk,Emily Dookun,James Chapman,Jodie Birch,Hanna Salmonowicz,Mikolaj Ogrodnik,Diana Jurk,Diana Jurk,Carole J. Proctor,Clara Correia-Melo,Stella Victorelli,Edward Fielder,Rolando Berlinguer-Palmini,A Owens,Laura C. Greaves,Kathy L Kolsky,Angelo Parini,Victorine Douin-Echinard,Nathan K. LeBrasseur,Helen M. Arthur,Simon Tual-Chalot,Marissa J. Schafer,Carolyn M Roos,Jordan D. Miller,Neil Robertson,Jelena Mann,Peter D. Adams,Peter D. Adams,Tamara Tchkonia,James L. Kirkland,Jeanne Mialet-Perez,Gavin D. Richardson,João F. Passos,João F. Passos +36 more
TL;DR: A mechanism by which senescence can occur and contribute to age‐related myocardial dysfunction and in the wider setting to ageing in post‐mitotic tissues is described.
Journal ArticleDOI
Monoamine oxidases as sources of oxidants in the heart.
Nina Kaludercic,Jeanne Mialet-Perez,Jeanne Mialet-Perez,Nazareno Paolocci,Angelo Parini,Angelo Parini,Fabio Di Lisa,Fabio Di Lisa +7 more
TL;DR: The role of MAO in catecholamine and serotonin clearance and cycling and cycling in relation to cardiac structure and function is discussed and both beneficial effects of their pharmacological or genetic inhibition along with potential adverse effects observed at baseline in MAO knockout mice are examined.
Journal ArticleDOI
p53-PGC-1α Pathway Mediates Oxidative Mitochondrial Damage and Cardiomyocyte Necrosis Induced by Monoamine Oxidase-A Upregulation: Role in Chronic Left Ventricular Dysfunction in Mice
Christelle Villeneuve,Céline Guilbeau-Frugier,Pierre Sicard,Olivier Lairez,Catherine Ordener,Thibaut Duparc,Damien De Paulis,Bettina Couderc,Odile Spreux-Varoquaux,Florence Tortosa,Anne Garnier,Claude Knauf,Philippe Valet,Elisabetta Borchi,Chiara Nediani,Abdallah Gharib,Michel Ovize,Marie-Bernadette Delisle,Angelo Parini,Jeanne Mialet-Perez +19 more
TL;DR: The first evidence that MAO-A upregulation in the heart causes oxidative mitochondrial damage, p53-dependent repression of PGC-1α, cardiomyocyte necrosis, and chronic ventricular dysfunction is provided.
Journal ArticleDOI
Autophagy in health and disease: focus on the cardiovascular system.
TL;DR: The current knowledge on the role of cardiovascular autophagy in physiological and pathophysiological conditions is reviewed.
Journal ArticleDOI
Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure
Yohan Santin,Yohan Santin,Pierre Sicard,Pierre Sicard,François Vigneron,François Vigneron,Céline Guilbeau-Frugier,Céline Guilbeau-Frugier,Marianne Dutaur,Marianne Dutaur,Olivier Lairez,Olivier Lairez,Bettina Couderc,Diego Manni,Viktor I. Korolchuk,Frank Lezoualc'h,Frank Lezoualc'h,Angelo Parini,Angelo Parini,Jeanne Mialet-Perez,Jeanne Mialet-Perez +20 more
TL;DR: It is demonstrated that the MAO-A/H2O2 axis has a negative impact on the elimination and recycling of mitochondria through the autophagy-lysosome pathway, which participates in cardiomyocyte death and HF.