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Anil Chandraker
Researcher at Brigham and Women's Hospital
Publications - 225
Citations - 11075
Anil Chandraker is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 51, co-authored 215 publications receiving 9892 citations. Previous affiliations of Anil Chandraker include Lahey Hospital & Medical Center & National Institutes of Health.
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Journal ArticleDOI
Deleterious Effect of CTLA4‐Ig on a Treg‐Dependent Transplant Model
Leonardo V. Riella,T. Liu,Jun Yang,Susanne Chock,Tetsunosuke Shimizu,Bechara Mfarrej,Ibrahim Batal,Xiang Xiao,Mohamed H. Sayegh,Anil Chandraker +9 more
TL;DR: The importance of the B7:CD28 pathway in Treg homeostasis in an in vivo transplant model is confirmed and hCTLA4Ig therapy may be deleterious in circumstances where engraftment is dependent on Tregs.
Journal ArticleDOI
The Novel Costimulatory Programmed Death Ligand 1/B7.1 Pathway Is Functional in Inhibiting Alloimmune Responses In Vivo
Jun Yang,Leonardo V. Riella,Leonardo V. Riella,Susanne Chock,Susanne Chock,Tao Liu,Tao Liu,Xiaozhi Zhao,Xiaozhi Zhao,Xueli Yuan,Xueli Yuan,Alison M. Paterson,Toshihiko Watanabe,Toshihiko Watanabe,Vijay K. Vanguri,Hideo Yagita,Miyuki Azuma,Bruce R. Blazar,Gordon J. Freeman,Scott J. Rodig,Arlene H. Sharpe,Anil Chandraker,Anil Chandraker,Mohamed H. Sayegh,Mohamed H. Sayegh +24 more
TL;DR: Functional data indicate that PDL1 interaction with B7.1 plays an important role in the inhibition of alloimmune responses in vivo and suggests a dominant direction for PDL 1 and B 7.1 interaction.
Journal ArticleDOI
Cutting Edge: Recipient MHC Class II Expression Is Required to Achieve Long-Term Survival of Murine Cardiac Allografts After Costimulatory Blockade
Akira Yamada,Anil Chandraker,Terri M. Laufer,Andrea J. Gerth,Mohamed H. Sayegh,Hugh Auchincloss +5 more
TL;DR: It is suggested that an active CD4+ response through the indirect pathway is necessary for costimulatory blockade to be effective in prolonging allograft survival.
Journal ArticleDOI
Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.
Thomas Wekerle,Mohamed H. Sayegh,Hiroshi Ito,Joshua Hill,Anil Chandraker,Denise A. Pearson,Kirsten G. Swenson,Guiling Zhao,Megan Sykes +8 more
TL;DR: One injection of anti-CD154 or CTLA4Ig overcomes the need for TI or prolonged host TCD in a preclinical model for the induction of mixed chimerism and deletional tolerance and thus further decreases the toxicity of this protocol.
Zeisberg, E.M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952-961
Elisabeth M. Zeisberg,Oleg Tarnavski,Michael Zeisberg,Adam L. Dorfman,Julie R. McMullen,Erika Gustafsson,Anil Chandraker,Xueli Yuan,William T. Pu,Anita B. Roberts,Eric G. Neilson,Mohamed H. Sayegh,Seigo Izumo,Raghu Kalluri +13 more