Ruihuan Chen

TL;DR: Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis, suggesting functional relevance of tumor subtype molecular signatures is suggested by the ability of cell line signatures to predict neurosphere growth.

TL;DR: The results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-Renewing cell types expressing a range of markers of forebrain lineage.

TL;DR: In this article, an antibody drug conjugate composition of matter useful for the diagnosis and treatment of tumors in mammals and methods of using those compositions of matter for the same were described.

TL;DR: Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro, providing insight into possible mechanisms contributing to the improved outcomes observed in patients with IDH 1/2 mutant gliomas.

TL;DR: It is demonstrated that xylitol at low concentration (O.5 mM) induced the expression of the L-PK/CAT construct in glucose-responsive mhAT3F hepatoma cells at the same level as 20 mM glucose, while it did not affect intracellular concentration of glucose 6-phosphate significantly.