Ann D. Cohen

TL;DR: In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significantAmyloid burden can remain cognitively normal, but this finding is based on relatively small numbers and needs to be replicated in larger cohorts.

TL;DR: Findings indicate the potential clinical utility of amyloid imaging for differential diagnosis in early-onset dementia and to support the clinical diagnosis of participants with AD dementia and noncarrier APOE ε4 status.

TL;DR: Postmortem evaluation of tissue from two parents of PS1C410Y subjects in this study confirmed extensive striatal amyloid deposition, along with typical cortical deposition, in these PS1 mutation carriers.

TL;DR: Results suggest that physical therapy may be beneficial in Parkinson's disease and show remarkable sparing of striatal DA, its metabolites, and the expression of the vesicular monoamine transporter, suggesting a decrease in the extent of DA neuron degeneration.