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Ann De Vos
Researcher at Katholieke Universiteit Leuven
Publications - 32
Citations - 1095
Ann De Vos is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Neurogranin & Biomarker (medicine). The author has an hindex of 13, co-authored 32 publications receiving 721 citations. Previous affiliations of Ann De Vos include Catholic University of Leuven.
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Journal ArticleDOI
The β-Secretase BACE1 in Alzheimer's Disease.
Harald Hampel,Robert Vassar,Bart De Strooper,Bart De Strooper,Bart De Strooper,John Hardy,Michael Willem,Neeraj Kumar Singh,John Zhou,Riqiang Yan,Eugeen Vanmechelen,Ann De Vos,Robert Nisticò,Massimo Corbo,Bruno P. Imbimbo,Johannes Streffer,Iryna Voytyuk,Iryna Voytyuk,Iryna Voytyuk,Maarten Timmers,Maarten Timmers,Amir Abbas Tahami Monfared,Amir Abbas Tahami Monfared,Michael C. Irizarry,Bruce Albala,Akihiko Koyama,Naoto Watanabe,Teiji Kimura,Lisa Yarenis,Simone Lista,Simone Lista,Lynn D. Kramer,Andrea Vergallo +32 more
TL;DR: BACE1 concentrations and rates of activity are increased in AD brains and body fluids, thereby supporting the hypothesis that BACE1 plays a critical role in AD pathophysiology, and is a prime drug target for slowing down Aβ production in early AD.
Journal ArticleDOI
C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease
Ann De Vos,Dirk Jacobs,Hanne Struyfs,Erik Fransen,Kerstin Andersson,Erik Portelius,Ulf Andreasson,Didier De Surgeloose,Daniëlle Hernalsteen,Kristel Sleegers,Caroline Robberecht,Christine Van Broeckhoven,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Sebastiaan Engelborghs,Eugeen Vanmechelen +16 more
TL;DR: In this paper, an enzyme-linked immunosorbent assay (ELISA) targeting neurogranin C-terminally was used to evaluate CSF biomarkers for AD diagnosis.
Journal ArticleDOI
Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease.
Andrea Vergallo,Andrea Vergallo,Lucile Megret,Simone Lista,Simone Lista,Enrica Cavedo,Enrica Cavedo,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Eugeen Vanmechelen,Ann De Vos,Marie-Odile Habert,Marie-Claude Potier,Bruno Dubois,Bruno Dubois,Christian Neri,Harald Hampel,Hovagim Bakardjian,Habib Benali,Hugo Bertin,Joel Bonheur,Laurie Boukadida,Nadia Boukerrou,E. Cavedo,E. Cavedo,Patrizia Andrea Chiesa,Olivier Colliot,Bruno Dubois,Bruno Dubois,Marion Dubois,Stéphane Epelbaum,Geoffroy Gagliardi,Remy Genthon,M.O. Habert,H. Hampel,Marion Houot,Aurélie Kas,F. Lamari,Marcel Levy,S. Lista,S. Lista,Christiane Metzinger,Fanny Mochel,Francis Nyasse,Catherine Poisson,M.C. Potier,Marie Revillon,Antonio Melo dos Santos,Katia Andrade,Marine Sole,Mohmed Surtee,Thiebaud de Schotten M,A. Vergallo,A. Vergallo,Nadjia Younsi,Lisi Flores Aguilar,Claudio Babiloni,Filippo Baldacci,Norbert Benda,Keith L. Black,Arun L.W. Bokde,Ubaldo Bonuccelli,Karl Broich,Francesco Cacciola,Juan I. Castrillo,Roberto Ceravolo,Patrizia A. Chiesa,Jean-Christophe Corvol,A.C. Cuello,Jeffrey L. Cummings,Herman Depypere,Andrea Duggento,Valentina Escott-Price,Howard J. Federoff,Maria Teresa Ferretti,Massimo S. Fiandaca,Richard Frank,Francesco Garaci,Hugo Geerts,Filippo Sean Giorgi,Manuela Graziani,Marion Haberkamp,Karl Herholz,Eric Karran,Seung Hyun Kim,Yosef Koronyo,Maya Koronyo-Hamaoui,Foudil Lamari,Todd Langevin,Stéphane Lehéricy,Jean Lorenceau,Dalila Mango,Mark Mapstone,Robert Nisticò,Sid E. O'Bryant,George L. W. Perry,Craig W. Ritchie,Simone Rossi,Amira Saidi,Emiliano Santarnecchi,Lon S. Schneider,Olaf Sporns,Nicola Toschi,Steven Verdooner,Nicolas Villain,Lindsay A. Welikovitch,Janet Woodcock,Erfan Younesi +108 more
TL;DR: Blood‐based biomarkers of pathophysiological brain amyloid β (Aβ) accumulation, particularly for preclinical target and large‐scale interventions, are warranted to effectively enrich Alzheimer's disease clinical trials and management.
Journal ArticleDOI
Protein folding diseases and neurodegeneration: Lessons learned from yeast
Joris Winderickx,Charlotte Delay,Charlotte Delay,Ann De Vos,H. Klinger,Klaartje Pellens,Thomas Vanhelmont,Fred Van Leuven,Piotr Zabrocki +8 more
TL;DR: The current knowledge gained by the use of so-called humanized yeasts in the field of Huntington's, Parkinson's and Alzheimer's diseases is reviewed.
Journal ArticleDOI
Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke
Ann De Vos,Maria Bjerke,Raf Brouns,Naomi De Roeck,Dirk Jacobs,Lien Van den Abbeele,Kaat Guldolf,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Sebastiaan Engelborghs,Eugeen Vanmechelen +13 more
TL;DR: Findings indicate that although plasma and CSF neurogranin may reflect the volume of acute cerebral ischemia, this synaptic protein is less likely to be a potential AIS biomarker.