J
Juan I. Castrillo
Researcher at University of Cambridge
Publications - 32
Citations - 1633
Juan I. Castrillo is an academic researcher from University of Cambridge. The author has contributed to research in topics: Systems biology & Chemostat. The author has an hindex of 19, co-authored 27 publications receiving 1463 citations. Previous affiliations of Juan I. Castrillo include Delft University of Technology & University of Manchester.
Papers
More filters
Journal ArticleDOI
Growth control of the eukaryote cell: a systems biology study in yeast
Juan I. Castrillo,Leo A. H. Zeef,David C. Hoyle,Nianshu Zhang,Andrew Hayes,David C. J. Gardner,Michael Cornell,June Petty,Luke Hakes,Leanne Wardleworth,Bharat M. Rash,Marie Brown,Warwick B. Dunn,David Broadhurst,Kerry O'Donoghue,Svenja Hester,Tom Dunkley,Sarah R. Hart,Neil Swainston,Peter Li,Simon J. Gaskell,Norman W. Paton,Kathryn S. Lilley,Douglas B. Kell,Stephen G. Oliver +24 more
TL;DR: This work constitutes a first comprehensive systems biology study on growth-rate control in the eukaryotic cell and has direct implications for advanced studies on cell growth, in vivo regulation of metabolic fluxes for comprehensive metabolic engineering, and for the design of genome-scale systems biology models of the eUKaryoticcell.
Journal ArticleDOI
An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry.
TL;DR: A method for the global analysis of yeast intracellular metabolites, based on electrospray mass spectrometry (ES-MS), has been developed and may be used for comparative analysis and screening of metabolite profiles of yeast strains and mutants under controlled conditions in order to elucidate gene function via metabolomics.
Journal ArticleDOI
Regulation of alcoholic fermentation in batch and chemostat cultures of Kluyveromyces lactis CBS 2359.
Janine Kiers,Anne-Marie Zeeman,Anne-Marie Zeeman,Marijke A. H. Luttik,Claudia Thiele,Juan I. Castrillo,H. Y. Steensma,H. Y. Steensma,Johannes P. van Dijken,Jack T. Pronk +9 more
TL;DR: It is concluded that in K. lactis, as in other Crabtree‐negative yeasts, the primary environmental trigger for occurrence of alcoholic fermentation is oxygen limitation.
Journal ArticleDOI
Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
André B. Canelas,Nicola Harrison,Alessandro Fazio,Jie Zhang,Juha-Pekka Pitkänen,Joost van den Brink,Barbara M. Bakker,Lara Bogner,Jildau Bouwman,Juan I. Castrillo,Ayca Cankorur,Pramote Chumnanpuen,Pascale Daran-Lapujade,Duygu Dikicioglu,Karen van Eunen,Jennifer C. Ewald,Joseph J. Heijnen,Betul Kirdar,Ismo Mattila,Femke I. C. Mensonides,Anja Niebel,Merja Penttilä,Jack T. Pronk,Matthias Reuss,Laura Salusjärvi,Uwe Sauer,David James Sherman,Martin Siemann-Herzberg,Hans V. Westerhoff,Johannes H. de Winde,Dina Petranovic,Stephen G. Oliver,Christopher T. Workman,Nicola Zamboni,Jens Nielsen +34 more
TL;DR: This paper characterized two yeast strains and hypothesizes that differences in phenotype are due to differences in protein metabolism, as well as showing significant differences in the maximum specific growth rate and biomass yield between the two strains.
Journal ArticleDOI
Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease.
Andrea Vergallo,Andrea Vergallo,Lucile Megret,Simone Lista,Simone Lista,Enrica Cavedo,Enrica Cavedo,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Eugeen Vanmechelen,Ann De Vos,Marie-Odile Habert,Marie-Claude Potier,Bruno Dubois,Bruno Dubois,Christian Neri,Harald Hampel,Hovagim Bakardjian,Habib Benali,Hugo Bertin,Joel Bonheur,Laurie Boukadida,Nadia Boukerrou,E. Cavedo,E. Cavedo,Patrizia Andrea Chiesa,Olivier Colliot,Bruno Dubois,Bruno Dubois,Marion Dubois,Stéphane Epelbaum,Geoffroy Gagliardi,Remy Genthon,M.O. Habert,H. Hampel,Marion Houot,Aurélie Kas,F. Lamari,Marcel Levy,S. Lista,S. Lista,Christiane Metzinger,Fanny Mochel,Francis Nyasse,Catherine Poisson,M.C. Potier,Marie Revillon,Antonio Melo dos Santos,Katia Andrade,Marine Sole,Mohmed Surtee,Thiebaud de Schotten M,A. Vergallo,A. Vergallo,Nadjia Younsi,Lisi Flores Aguilar,Claudio Babiloni,Filippo Baldacci,Norbert Benda,Keith L. Black,Arun L.W. Bokde,Ubaldo Bonuccelli,Karl Broich,Francesco Cacciola,Juan I. Castrillo,Roberto Ceravolo,Patrizia A. Chiesa,Jean-Christophe Corvol,A.C. Cuello,Jeffrey L. Cummings,Herman Depypere,Andrea Duggento,Valentina Escott-Price,Howard J. Federoff,Maria Teresa Ferretti,Massimo S. Fiandaca,Richard Frank,Francesco Garaci,Hugo Geerts,Filippo Sean Giorgi,Manuela Graziani,Marion Haberkamp,Karl Herholz,Eric Karran,Seung Hyun Kim,Yosef Koronyo,Maya Koronyo-Hamaoui,Foudil Lamari,Todd Langevin,Stéphane Lehéricy,Jean Lorenceau,Dalila Mango,Mark Mapstone,Robert Nisticò,Sid E. O'Bryant,George L. W. Perry,Craig W. Ritchie,Simone Rossi,Amira Saidi,Emiliano Santarnecchi,Lon S. Schneider,Olaf Sporns,Nicola Toschi,Steven Verdooner,Nicolas Villain,Lindsay A. Welikovitch,Janet Woodcock,Erfan Younesi +108 more
TL;DR: Blood‐based biomarkers of pathophysiological brain amyloid β (Aβ) accumulation, particularly for preclinical target and large‐scale interventions, are warranted to effectively enrich Alzheimer's disease clinical trials and management.