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Ann-Kathrin Reuschl
Researcher at University College London
Publications - 9
Citations - 199
Ann-Kathrin Reuschl is an academic researcher from University College London. The author has contributed to research in topics: Innate immune system & Viral replication. The author has an hindex of 5, co-authored 8 publications receiving 84 citations.
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Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant
Lucy Thorne,Mehdi Bouhaddou,Ann-Kathrin Reuschl,Lorena Zuliani-Alvarez,Benjamin J. Polacco,Adrian Pelin,Jyoti Batra,Matthew Whelan,Manisha Ummadi,Ajda Roic,Jane Turner,Kirsten Obernier,Hannes Braberg,Margaret Soucheray,Alicia L. Richards,Kuei-Ho Chen,Bhavya Harjai,Danish Memon,Myra Hosmillo,Joseph Hiatt,Aminu S Jahun,Ian Goodfellow,Mahdad Noursadeghi,Jacqueline M. Fabius,Kevan M. Shokat,Natalia Jura,Kliment A. Verba,Kliment A. Verba,Pedro Beltrao,Danielle L. Swaney,Adolfo García-Sastre,Clare Jolly,Greg J. Towers,Nevan J. Krogan +33 more
TL;DR: In this article, the authors used unbiased abundance proteomics, phosphoproteomics, mRNA sequencing and viral replication assays to show that B.1.7 isolates more effectively suppress host innate immune responses in airway epithelial cells.
Posted ContentDOI
SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation
Lucy Thorne,Ann-Kathrin Reuschl,Lorena Zuliani-Alvarez,Matthew Whelan,Mahdad Noursadeghi,Clare Jolly,Greg J. Towers +6 more
TL;DR: In this article, the authors found that SARS-CoV-2 replicates rapidly in lung epithelial cells despite triggering a robust innate immune response through activation of cytoplasmic RNA-ensors RIG-I and MDA5.
Posted ContentDOI
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant
Ann-Kathrin Reuschl,Lucy Thorne,Lorena Zuliani Alvarez,Mehdi Bouhaddou,Kirsten Obernier,Joseph Hiatt,Margaret Soucheray,Jane Turner,Jacqueline M. Fabius,Gina T. Nguyen,Danielle L. Swaney,Romel Rosales,Kris M. White,Pablo Aviles,Ilsa T Kirby,James E. Melnyk,Ying Shi,Ziyang Zhang,Kevan M. Shokat,Adolfo García-Sastre,Clare Jolly,Gregory J Towers,Nevan J. Krogan +22 more
TL;DR: In this article, two host-directed drugs, plitidepsin (aplidin; inhibits translation elongation factor eEF1A) and ralimetinib (inhibits p38 MAP kinase cascade), as well as remdesivir, were evaluated in both human gastrointestinal and lung epithelial cell lines.
Posted ContentDOI
Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2
Samuel James Dicken,Matthew J Murray,Lucy Thorne,Ann-Kathrin Reuschl,Calum Forrest,Maaroothen Ganeshalingham,Luke Muir,Mphatso D Kalemera,Machaela Palor,Laura E. McCoy,Clare Jolly,Greg J. Towers,Matthew B. Reeves,Joe Grove +13 more
TL;DR: In this article, the authors examined virus entry by the B.1.7 lineage, commonly referred to as the UK/Kent variant, and found that amino acid deletions within the N-terminal domain (NTD) of spike were important for efficient entry by B. 1.7.
Posted ContentDOI
The local and systemic response to SARS-CoV-2 infection in children and adults
Masahiro Yoshida,Masahiro Yoshida,Kaylee B Worlock,Ni Huang,Rik G.H. Lindeboom,Colin R. Butler,Natsuhiko Kumasaka,Cecilia Domínguez Conde,Lira Mamanova,Liam Bolt,Laura Richardson,Krzysztof Polanski,Elo Madissoon,Elo Madissoon,Josephine Barnes,Jessica Allen-Hyttinen,Eliz Kilich,Brendan C Jones,Angus de Wilton,Anna Wilbrey-Clark,Waradon Sungnak,Jan Patrick Prett,Elena Prigmore,Henry Yung,Henry Yung,Puja Mehta,Puja Mehta,Aarash Saleh,A Saigal,Vivian Chu,Jonathan M. Cohen,Clare Cane,Aikaterini Iordanidou,Soichi Shibuya,Ann-Kathrin Reuschl,A. Christine Argento,Richard G. Wunderink,Sean B. Smith,Taylor A. Poor,Catherine A Gao,Jane Dematte,NU Script Study Investigators,Gary Reynolds,Muzlifah Haniffa,Georgina Bowyer,Matthew L Coates,Matthew L Coates,Menna R. Clatworthy,Fernando J Calero-Nieto,Berthold Göttgens,Neil J. Sebire,Clare Jolly,Paolo De Coppi,Claire Smith,Alexander V. Misharin,Sam M. Janes,Sam M. Janes,Sarah A. Teichmann,Sarah A. Teichmann,Marko Nikolic,Marko Nikolic,Kerstin B. Meyer +61 more
TL;DR: In this paper, a healthy reference multi-omics single cell data set from children (n=30) was generated and compared with equivalent data from severe paediatric and adult COVID-19 patients (total n=27), from the same three types of samples: upper and lower airways and blood.