Anna Karlsson-Bengtsson

TL;DR: Novel functional roles of MPO glycans are reported, providing new insight into neutrophil-mediated immunity and molecular modelling revealed that hyper-truncated Asn355-glycans positioned in the MPO-ceruloplasmin interface are critical for uninterrupted inhibition.

TL;DR: This comprehensive neutrophil granule glycome map, the first of its kind, highlights novel granule-specific glycosylation features and is a crucial first step toward a better understanding of the mechanisms regulating protein glycosYLation during neutrophils granulopoiesis and a more detailed understanding of neutrophIL biology and function.

TL;DR: It is confirmed that the core 2 O-linked glycans mediate this lubricin–galectin-3 interaction, shown by surface plasmon resonance data indicating that recombinant lubricin (rhPRG4) devoid of core 2 structures did not bind to recombinant galectin -3.

TL;DR: This comprehensive neutrophil granule glycome map, the first of its kind, highlights novel granule-specific glycosylation features and is a crucial first step towards a better understanding of the mechanisms regulating protein glycosolation during neutrophils granulopoiesis and a more detailed understanding of neutrophIL biology and function.

TL;DR: Galectin-3 has been shown to have immunomodulatory properties that may affect the microglia phenotype and subsequent development of injury in the neonatal brain, but it is unclear if Galectin3 has similar effects on infectious and sterile inflammation as discussed by the authors.