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Ian Loke
Researcher at Macquarie University
Publications - 16
Citations - 481
Ian Loke is an academic researcher from Macquarie University. The author has contributed to research in topics: Glycosylation & N-linked glycosylation. The author has an hindex of 10, co-authored 15 publications receiving 351 citations. Previous affiliations of Ian Loke include National University of Singapore.
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Journal ArticleDOI
Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Morten Thaysen-Andersen,Vignesh Venkatakrishnan,Ian Loke,Christine Laurini,Simone Diestel,Benjamin L. Parker,Nicolle H. Packer +6 more
TL;DR: It is the first to document that human neutrophils produce, store and, upon activation, selectively secrete bioactive paucimannosidic proteins into sputum of lungs undergoing pathogen-based inflammation.
Journal ArticleDOI
Emerging roles of protein mannosylation in inflammation and infection.
TL;DR: This review summarises the increasing volume of literature covering human and non-human protein mannosylation, including their structures, biosynthesis and spatiotemporal expression, and covers their known interactions with specialised host and microbial mannose-recognising C-type lectin receptors (mrCLRs) and antibodies (mrAbs) during inflammation and pathogen infection.
Journal ArticleDOI
Paucimannose-Rich N-glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions.
TL;DR: Observations support that the unusual HNE N-glycosylation, here reported for the first time, is involved in modulating multiple immune functions central to inflammation and infection.
Journal ArticleDOI
Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G
TL;DR: High-resolution/mass accuracy LC-MS profiling of intact nCG confirmed the Asn71-glycoprofile and identified two C-terminal truncation variants at Arg243 and Ser244, both displaying oxidation of solvent-accessible Met152.
Journal ArticleDOI
Protein paucimannosylation is an enriched N-glycosylation signature of human cancers
Sayantani Chatterjee,Ling Y. Lee,Ling Y. Lee,Rebeca Kawahara,Rebeca Kawahara,Jodie L. Abrahams,Jodie L. Abrahams,Barbara Adamczyk,Merrina Anugraham,Merrina Anugraham,Christopher Ashwood,Christopher Ashwood,Zeynep Sumer-Bayraktar,Zeynep Sumer-Bayraktar,Matthew T. Briggs,Jenny H. L. Chik,Jenny H. L. Chik,Arun V. Everest-Dass,Arun V. Everest-Dass,Sarah Förster,Hannes Hinneburg,Katia R. M. Leite,Ian Loke,Ian Loke,Uwe Möginger,Edward S. X. Moh,Miyako Nakano,Miyako Nakano,Saulo Recuero,Manveen K. Sethi,Manveen K. Sethi,Miguel Srougi,Kathrin Stavenhagen,Kathrin Stavenhagen,Vignesh Venkatakrishnan,Katherine Wongtrakul-Kish,Katherine Wongtrakul-Kish,Simone Diestel,Peter Hoffmann,Niclas G. Karlsson,Daniel Kolarich,Mark P. Molloy,Mark P. Molloy,Michael Muders,Martin K. Oehler,Nicolle H. Packer,Nicolle H. Packer,Giuseppe Palmisano,Morten Thaysen-Andersen +48 more
TL;DR: An intriguing association between protein paucimannosylation and human cancers warrants further exploration to detail the biosynthesis, cellular location(s), protein carriers, and functions of paucIMannosidic epitopes in tumorigenesis and metastasis.