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Anna Krassowska
Researcher at University of Edinburgh
Publications - 3
Citations - 686
Anna Krassowska is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Cellular differentiation & Stem cell. The author has an hindex of 3, co-authored 3 publications receiving 655 citations. Previous affiliations of Anna Krassowska include Western General Hospital.
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Journal ArticleDOI
Severe Global DNA Hypomethylation Blocks Differentiation and Induces Histone Hyperacetylation in Embryonic Stem Cells
Melany Jackson,Anna Krassowska,Nick Gilbert,Timothy Chevassut,Lesley M. Forrester,J. D. Ansell,Bernard Ramsahoye +6 more
TL;DR: It is shown that successful terminal differentiation is not dependent simply on adequate methylation levels, and there is an absolute requirement that the methylation be delivered by the maintenance enzyme Dnmt1.
Journal ArticleDOI
Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches
Maria H. Ledran,Anna Krassowska,Lyle Armstrong,Ian Dimmick,Jonas Renström,Roland Lang,Sun Yung,Mauro Santibanez-Coref,Elaine Dzierzak,Miodrag Stojkovic,Robert A.J. Oostendorp,Lesley M. Forrester,Majlinda Lako +12 more
TL;DR: Investigation of coculture with monolayers of cells derived from mouse AGM and fetal liver, or with stromal cell lines derived from these tissues, found that under such conditions hESC-derived differentiating cells formed early hematopoietic progenitors, with a peak at day 18-21 of differentiation that corresponded to the highest CD34 expression.
Journal ArticleDOI
Promotion of haematopoietic activity in embryonic stem cells by the aorta-gonad-mesonephros microenvironment.
Anna Krassowska,Sabrina Gordon-Keylock,Kay Samuel,Derek S. Gilchrist,Elaine Dzierzak,Robert A.J. Oostendorp,Lesley M. Forrester,J. D. Ansell +7 more
TL;DR: It is concluded that factors promoting the haematopoietic activity of differentiating ES cells present in primary AGM explants are partially retained in the AM20.1B4 stromal cell line and that these factors are likely to be different to those required for adult HSC maintenance.