Tsz-Leung To

TL;DR: MitoCarta3.0, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome, is introduced and includes manually curated annotations of sub-mitochondrial localization and MitoPathway annotations, spanning seven broad functional categories relevant to mitochondria.

TL;DR: Using a synthetic system in budding yeast, it is shown that positive feedback involving a promoter with multiple transcription factor (TF) binding sites can induce a steady-state bimodal response without cooperative binding of the TF.

TL;DR: These simulations closely replicate experimental data and predict that heterogeneous oscillations arise from small differences in the molecular parameters between cells, that damped oscillators participate in entrainment and synchrony of the ensemble of cells, and that constant light desynchronizes oscillators by maximizing VIP release.

TL;DR: This resource performs genome-wide CRISPR growth screens at 21%, 5%, and 1% oxygen to systematically identify gene knockouts with relative fitness defects in high oxygen or low oxygen, and links hundreds of genes to oxygen homeostasis.

TL;DR: Perhaps paradoxically, certain forms of mitochondrial dysfunction may best be buffered with "second site" inhibitors to the organelle, which benefits cells by rebalancing redox cofactors, increasing reductive carboxylation, and promoting glycolysis.