L
Luca Giorgetti
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 57
Citations - 5631
Luca Giorgetti is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Chromosome conformation capture & XIST. The author has an hindex of 19, co-authored 44 publications receiving 4493 citations. Previous affiliations of Luca Giorgetti include European Institute of Oncology & Centre national de la recherche scientifique.
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Journal ArticleDOI
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Elphège P. Nora,Bryan R. Lajoie,Edda G. Schulz,Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Ikuhiro Okamoto,Ikuhiro Okamoto,Ikuhiro Okamoto,Nicolas Servant,Nicolas Servant,Nicolas Servant,Tristan Piolot,Tristan Piolot,Tristan Piolot,Nynke L. van Berkum,Johannes Meisig,John W. Sedat,Joost Gribnau,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot,Nils Blüthgen,Job Dekker,Edith Heard,Edith Heard,Edith Heard +26 more
TL;DR: In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, this study sets the stage for the full genetic dissection of the mouse X-inactivation centre.
Journal ArticleDOI
Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription
Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Rafael Galupa,Rafael Galupa,Rafael Galupa,Elphège P. Nora,Tristan Piolot,Tristan Piolot,Tristan Piolot,Job Dekker,Guido Tiana,Edith Heard +12 more
TL;DR: It is demonstrated that contacts between potential regulatory elements occur in the context of fluctuating structures rather than stable loops and proposed that such fluctuations may contribute to asymmetric expression in the Xic during X inactivation.
Journal ArticleDOI
Structural organization of the inactive X chromosome in the mouse
Luca Giorgetti,Luca Giorgetti,Bryan R. Lajoie,Ava C. Carter,Mikael Attia,Ye Zhan,Jin Xu,Chong-Jian Chen,Noam Kaplan,Howard Y. Chang,Edith Heard,Edith Heard,Job Dekker +12 more
TL;DR: A crucial role is demonstrated for Xist and the DXZ4-containing boundary in shaping Xi chromosome structure using allele-specific genome-wide chromosome conformation capture (Hi-C) analysis, an assay for transposase-accessible chromatin with high throughput sequencing (ATAC–seq) and RNA sequencing, and deletion of the boundary disrupts mega-domain formation.
Journal ArticleDOI
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments
Vlad C. Seitan,Andre J. Faure,Ye Zhan,Rachel Patton McCord,Bryan R. Lajoie,Elizabeth Ing-Simmons,Boris Lenhard,Luca Giorgetti,Edith Heard,Amanda G. Fisher,Paul Flicek,Paul Flicek,Job Dekker,Matthias Merkenschlager +13 more
TL;DR: These findings indicate that cohesin-mediated long-range interactions facilitate discrete gene expression states within preexisting chromosomal compartments, suggesting an important role for cohesIn in genome organization.
Journal ArticleDOI
The effect of surface nanometre-scale morphology on protein adsorption.
Pasquale Emanuele Scopelliti,Antonio Borgonovo,Marco Indrieri,Luca Giorgetti,Luca Giorgetti,G. Bongiorno,Roberta Carbone,Alessandro Podestà,Paolo Milani +8 more
TL;DR: The results show that the adsorption of proteins depends significantly on surface nanostructure and that the relevant morphological parameter regulating the protein adsorbed proteins process is the nanometric pore shape.