M
Mary E. Haas
Researcher at Broad Institute
Publications - 37
Citations - 4758
Mary E. Haas is an academic researcher from Broad Institute. The author has contributed to research in topics: Disease & Genome-wide association study. The author has an hindex of 17, co-authored 31 publications receiving 2634 citations. Previous affiliations of Mary E. Haas include Harvard University & United States Department of Veterans Affairs.
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Journal ArticleDOI
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
Amit Khera,Mark Chaffin,Krishna G. Aragam,Mary E. Haas,Carolina Roselli,Seung Hoan Choi,Pradeep Natarajan,Eric S. Lander,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor,Sekar Kathiresan +12 more
TL;DR: Genome-wide polygenic risk scores derived from GWAS data for five common diseases can identify subgroups of the population with risk approaching or exceeding that of a monogenic mutation.
Journal ArticleDOI
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
Sneha Rath,Sneha Rath,Rohit Sharma,Rohit Sharma,Rahul Gupta,Rahul Gupta,Tslil Ast,Tslil Ast,Connie Chan,Connie Chan,Timothy J. Durham,Timothy J. Durham,Russell P. Goodman,Russell P. Goodman,Zenon Grabarek,Zenon Grabarek,Mary E. Haas,Mary E. Haas,Wendy H. W. Hung,Wendy H. W. Hung,Pallavi R. Joshi,Pallavi R. Joshi,Alexis A. Jourdain,Alexis A. Jourdain,Sharon H. Kim,Sharon H. Kim,Anna V. Kotrys,Anna V. Kotrys,Stephanie S Lam,Stephanie S Lam,Jason G. McCoy,Jason G. McCoy,Joshua D. Meisel,Joshua D. Meisel,Maria Miranda,Maria Miranda,Apekshya Panda,Apekshya Panda,Anupam Patgiri,Anupam Patgiri,Robert S. Rogers,Robert S. Rogers,Shayan Sadre,Shayan Sadre,Hardik Shah,Hardik Shah,Owen S. Skinner,Owen S. Skinner,Tsz-Leung To,Tsz-Leung To,Melissa A. Walker,Melissa A. Walker,Hong Wang,Hong Wang,Patrick S. Ward,Patrick S. Ward,Jordan Wengrod,Jordan Wengrod,Chen-Ching Yuan,Chen-Ching Yuan,Sarah E. Calvo,Sarah E. Calvo,Vamsi K. Mootha,Vamsi K. Mootha +63 more
TL;DR: MitoCarta3.0, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome, is introduced and includes manually curated annotations of sub-mitochondrial localization and MitoPathway annotations, spanning seven broad functional categories relevant to mitochondria.
Journal ArticleDOI
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
Amit Khera,Mark Chaffin,Kaitlin H Wade,Sohail Zahid,Joseph Brancale,Rui Xia,Marina T. DiStefano,Ozlem Senol-Cosar,Ozlem Senol-Cosar,Ozlem Senol-Cosar,Mary E. Haas,Alexander G. Bick,Krishna G. Aragam,Eric S. Lander,George Davey Smith,Heather Mason-Suares,Heather Mason-Suares,Heather Mason-Suares,Myriam Fornage,Matthew S. Lebo,Matthew S. Lebo,Matthew S. Lebo,Nicholas J. Timpson,Lee M. Kaplan,Sekar Kathiresan +24 more
TL;DR: A new polygenic predictor comprised of 2.1 million common variants to quantify inherited susceptibility to obesity is derived and validated and test this predictor in more than 300,000 individuals ranging from middle age to birth.
Journal ArticleDOI
Biological and clinical insights from genetics of insomnia symptoms
Jacqueline M. Lane,Jacqueline M. Lane,Samuel E. Jones,Hassan S. Dashti,Hassan S. Dashti,Andrew R. Wood,Krishna G. Aragam,Vincent T. van Hees,Linn B Strand,Bendik S. Winsvold,Bendik S. Winsvold,Heming Wang,Heming Wang,Heming Wang,Jack Bowden,Yanwei Song,Yanwei Song,Yanwei Song,Krunal Patel,Krunal Patel,Simon G. Anderson,Simon G. Anderson,Robin N Beaumont,David A. Bechtold,Brian E. Cade,Brian E. Cade,Brian E. Cade,Mary E. Haas,Mary E. Haas,Sekar Kathiresan,Max A. Little,Max A. Little,Annemarie I. Luik,Annemarie I. Luik,Andrew S. I. Loudon,Shaun Purcell,Rebecca C Richmond,Frank A.J.L. Scheer,Frank A.J.L. Scheer,Frank A.J.L. Scheer,Barbara Schormair,Jessica Tyrrell,John W. Winkelman,Juliane Winkelmann,Hunt All In Sleep,Kristian Hveem,Chen Zhao,Jonas B. Nielsen,Cristen J. Willer,Susan Redline,Kai Spiegelhalder,Simon D. Kyle,David W. Ray,David W. Ray,John-Anker Zwart,John-Anker Zwart,Ben Michael Brumpton,Ben Michael Brumpton,Timothy M. Frayling,Debbie A Lawlor,Martin K. Rutter,Martin K. Rutter,Michael N. Weedon,Richa Saxena,Richa Saxena +64 more
TL;DR: Genome-wide association analyses identify 57 loci associated with insomnia symptoms and provide evidence of shared genetic architecture between insomnia and cardiometabolic, behavioral, psychiatric and reproductive traits.
Journal ArticleDOI
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
Joel T. Haas,Ji Miao,Dipanjan Chanda,Yanning Wang,Enpeng Zhao,Mary E. Haas,Matthew D. Hirschey,Bhavapriya Vaitheesvaran,Robert V. Farese,Irwin J. Kurland,Mark J. Graham,Rosanne M. Crooke,Fabienne Foufelle,Sudha B. Biddinger +13 more
TL;DR: Insulin signaling becomes more important in the pathological context of obesity, as knockdown of the insulin receptor in ob/ob mice, a model of Type 2 diabetes, abolishes the induction of SREBP-1c and its targets by obesity and ameliorates steatosis.