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Annabel Strife
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 59
Citations - 3371
Annabel Strife is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Chronic myelogenous leukemia & Progenitor cell. The author has an hindex of 31, co-authored 59 publications receiving 3346 citations. Previous affiliations of Annabel Strife include Chiron Corporation & Cornell University.
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Journal ArticleDOI
p62dok: A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells
Nick Carpino,David Wisniewski,Annabel Strife,Daniel R. Marshak,Ryuji Kobayashi,Bruce Stillman,Bayard D. Clarkson +6 more
TL;DR: Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine-phosphorylated protein that migrates at 62 kDa by SDS-PAGE and associates with the p120 ras GTPase-activating protein (GAP).
Journal Article
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.
David Wisniewski,C Lambek,Chongyuan Liu,Annabel Strife,Darren R. Veach,Bhushan Nagar,Bhushan Nagar,Matthew A. Young,Matthew A. Young,Thomas Schindler,Thomas Schindler,William G. Bornmann,Joseph R. Bertino,John Kuriyan,John Kuriyan,Bayard D. Clarkson +15 more
TL;DR: Compared with other pyrido[2,3-d]pyrimidine analogues studied, PD166326 was the most potent inhibitor of Bcr-Abl-dependent cell growth and PD173955 inhibited kit ligand-dependent c-kit autophosphorylation and had a lesser effect on interleukin 3-dependent or granulocyte macrophage colony-stimulating factor-induced cell growth.
Journal ArticleDOI
Growth characteristics of leukemic and normal hematopoietic cells in Ph' + chronic myelogenous leukemia and effects of intensive treatment.
Tatsuhiko Goto,Masaru Nishikori,Zalmen A. Arlin,Timothy Gee,Sanford Kempin,Joseph H. Burchenal,Annabel Strife,David Wisniewski,C Lambek,Claudia Little,Suresh C. Jhanwar,Raju S.K. Chaganti,Bayard D. Clarkson +12 more
TL;DR: The proliferative and differentiation characteristics of leukemic cells from chronic phase (Ph’ + ) CML were examined in vitro and compared to those of hematopoietic precursors from normal individuals.
Journal ArticleDOI
Monoclonal antibody YB5.B8 identifies the human c-kit protein product
Norma B. Lerner,Karl H. Nocka,Stephen R. Cole,Feihua Qiu,Annabel Strife,Leonie K. Ashman,Peter Besmer +6 more
TL;DR: Experiments provide evidence that the YB5.B8 antigen and the c-kit protein product are identical and raise certain hypotheses regarding the role of c-Kit in AML.
Journal ArticleDOI
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.
David Wisniewski,David Wisniewski,David Wisniewski,Annabel Strife,Annabel Strife,Annabel Strife,Steve Swendeman,Steve Swendeman,Steve Swendeman,Hediye Erdjument-Bromage,Hediye Erdjument-Bromage,Hediye Erdjument-Bromage,Scott Geromanos,Scott Geromanos,Scott Geromanos,W. Michael Kavanaugh,W. Michael Kavanaugh,W. Michael Kavanaugh,Paul Tempst,Paul Tempst,Paul Tempst,Bayard D. Clarkson,Bayard D. Clarkson,Bayard D. Clarkson +23 more
TL;DR: The purification and mass spectrometric identification of a 155-kD tyrosine phosphorylated protein associated with src homologous and collagen gene (SHC) from p210(bcr/abl)-expressing hematopoietic cells is described as SHIP2, a recently reported, unique SH2-domain-containing protein closely related to phosphatidylinositol polyphosphatase SHIP.