Anne-Britta Koehler

TL;DR: It is demonstrated that AhR senses distinct bacterial virulence factors and controls antibacterial responses, supporting a previously unidentified role for AhR as an intracellular pattern recognition receptor, and identifying bacterial pigments as a new class of pathogen-associated molecular patterns.

TL;DR: In this article, the authors investigated the underlying biological mechanisms elicited by the recombinant BCG ΔureC::hly (rBCG) vaccine candidate relevant to its protective efficacy.

TL;DR: Endocytosis facilitates internalization of eCDNs, and the DNA sensor cGAS facilitates sensing of endocytosed CDNs, their perinuclear accumulation, and subsequent STING‐dependent release of type I IFN.

TL;DR: It is demonstrated that Henna and its major pigment, the naphthoquinone Lawsone activate AhR, both in vitro and in vivo, and how the physiopathological context determines beneficial and detrimental outcomes is revealed.

TL;DR: It is demonstrated that Henna and its major pigment, the naphthoquinone Lawsone activate AhR, both in vitro and in vivo, and how the physiopathological context determines beneficial and detrimental outcomes is revealed.