Anne-Cécile Déclais

TL;DR: The identification of human SLX4, a scaffold for DNA repair nucleases XPF-ERCC1, MUS81-EME1, and SLX1 is described and data show thatSLX4 is a regulator of structure-specific nucleases and that SLX 4 and SLx1 are important regulators of genome stability in human cells.

TL;DR: Relative rates indicate that multiple conformer transitions occur at each intermediate step of branch migration, allowing the junction to reach conformational equilibrium, providing a mechanism whereby the sequence-dependent conformational bias could determine the extent of genetic exchange upon junction resolution.

TL;DR: A highly conserved protein is described, KIAA1018/MTMR15/FAN1, that interacts with, and is recruited to sites of DNA damage by, the monoubiquitinated form of FANCD2, which at least partly explains how ubiquitination of FANSCD2 promotes DNA repair.

TL;DR: It is shown that SLX1, like MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be independent of HJ cleavage, at least in mouse cells.

TL;DR: It is proposed that TRF2 contributes to t‐loop stabilisation by stimulating HJ formation and by preventing resolvase cleavage, and this findings provide novel insights into the interplay between telomere protection and homologous recombination.