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Anne Stary
Researcher at Centre national de la recherche scientifique
Publications - 45
Citations - 2214
Anne Stary is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: DNA repair & Xeroderma pigmentosum. The author has an hindex of 27, co-authored 44 publications receiving 2114 citations. Previous affiliations of Anne Stary include University of Paris-Sud & Institut Gustave Roussy.
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XPD Mutations Prevent TFIIH-Dependent Transactivation by Nuclear Receptors and Phosphorylation of RARα
TL;DR: It is demonstrated that the cdk7 kinase of TFIIH phosphorylates the nuclear receptor, then allowing ligand-dependent control of the activation of the hormone-responsive genes.
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Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients
Bernard C. Broughton,Agnès Cordonnier,Wim J. Kleijer,Nicolaas G. J. Jaspers,Heather Fawcett,Anja Raams,Victor H. Garritsen,Anne Stary,Marie-Françoise Avril,François Boudsocq,Chikahide Masutani,Fumio Hanaoka,Robert P. P. Fuchs,Alain Sarasin,Alan R. Lehmann +14 more
TL;DR: It is anticipated that protein in XP-V cells will not be localized in the nucleus nor will it be relocalized into replication foci during DNA replication, and the spectrum of both missense and truncating mutations is markedly skewed toward the N-terminal half of the protein.
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Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells
TL;DR: The functional complementation of XP-V cells by pol η reduced the mutation frequencies both at CG and TA base pairs and restored UV mutagenesis to a normal level and clearly shows the protective role of polη against UV-induced lesions and the activation by UV of pol ε-independent mutagenic processes.
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DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination
Ahmad Faili,Said Aoufouchi,Sandra Weller,Françoise Vuillier,Anne Stary,Alain Sarasin,Claude-Agnès Reynaud,Jean-Claude Weill +7 more
TL;DR: It is shown, by analyzing switched memory B cells from two XP-V patients, that pol η is also an A/T mutator during CSR, in both the switch region of tandem repeats as well as upstream of it, thus suggesting that the same error-prone translesional polymerases are involved, together with AID, inboth processes.
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Cell Survival and Shuttle Vector Mutagenesis Induced by Ultraviolet A and Ultraviolet B Radiation in a Human Cell Line
TL;DR: The UVA-induced mutation spectrum that the authors have observed in human cells may help help to elucidate the mechanism of skin carcinogenesis.