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Anne-Theres Henze
Researcher at Katholieke Universiteit Leuven
Publications - 9
Citations - 495
Anne-Theres Henze is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Tumor microenvironment & Metastasis. The author has an hindex of 4, co-authored 9 publications receiving 394 citations. Previous affiliations of Anne-Theres Henze include Flanders Institute for Biotechnology.
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Journal ArticleDOI
The impact of hypoxia on tumor-associated macrophages.
TL;DR: A careful characterization and understanding of this macrophage differentiation state is needed in order to efficiently tailor cancer therapy.
Journal ArticleDOI
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity
Rodrigo Leite de Oliveira,Sofie Deschoemaeker,Anne-Theres Henze,Koen Debackere,Veronica Finisguerra,Yukiji Takeda,Carmen Roncal,Daniela Dettori,Evelyne Tack,Yannick Jönsson,Lorenzo Veschini,Annelies Peeters,Andrey Anisimov,Matthias Hofmann,Kari Alitalo,Myriam Baes,Jan D'hooge,Peter Carmeliet,Massimiliano Mazzone +18 more
TL;DR: It is shown that tumor vessel normalization by genetic inactivation of Phd2 increases the delivery of chemotherapeutics to the tumor and, hence, their antitumor and antimetastatic effect, regardless of combined inhibition of PhD2 in cancer cells.
Journal ArticleDOI
PHD2 regulates arteriogenic macrophages through TIE2 signalling
Alexander Hamm,Lorenzo Veschini,Yukiji Takeda,Sandra Costa,Estelle Delamarre,Mario Leonardo Squadrito,Anne-Theres Henze,Mathias Wenes,Jens Serneels,Ferdinando Pucci,Carmen Roncal,Andrey Anisimov,Kari Alitalo,Michele De Palma,Massimiliano Mazzone +14 more
TL;DR: Gene silencing and cell depletion strategies demonstrate that TIE2 induction in macrophages is required to promote their proarteriogenic functions, enabling collateral vessel formation following arterial obstruction, suggesting possible new venues for the treatment of ischaemic disorders.
Journal ArticleDOI
Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival
Serafim Kiriakidis,Anne-Theres Henze,Ilona Kruszynska-Ziaja,Konstantinos Skobridis,Vassiliki Theodorou,Ewa M. Paleolog,Massimiliano Mazzone +6 more
TL;DR: The data support the concept that FIH‐1 may interact with Notch2 and repress its activity, thereby playing a critical role in controlling the survival of vascular endothelial cells, and pave the way toward novel, antiangiogenic strategies in disorders that are characterized by excessive vascular growth.
Proceedings ArticleDOI
Abstract PR11: Increased matrix stiffness induces CCN1 mediated upregulation of N-Cadherin in endothelial cells: Implications for cancer cell metastasis
Steven Reid,Jens Serneels,Lisa J. Neilson,Anne-Theres Henze,Juan Ramon Hernandez-Fernaud,Ralf H. Adams,Karen Blyth,Massimiliano Mazzone,Sara Zanivan +8 more
TL;DR: This work determines an unprecedented mechanism through which CCN1 in the stromal cells promotes invasion of cancer cells, and provides evidence that targetingCCN1 therapeutically in the clinic may decrease the spread of cancer from the perspective of the endothelial cells.