M
Mathias Wenes
Researcher at Katholieke Universiteit Leuven
Publications - 16
Citations - 1841
Mathias Wenes is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Cancer & Angiogenesis. The author has an hindex of 10, co-authored 13 publications receiving 1440 citations.
Papers
More filters
Journal ArticleDOI
Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity
Andrea Casazza,Damya Laoui,Mathias Wenes,Sabrina Rizzolio,Nicklas Bassani,Marco Mambretti,Sofie Deschoemaeker,Jo A. Van Ginderachter,Luca Tamagnone,Massimiliano Mazzone +9 more
TL;DR: It is reported that hypoxia-induced Semaphorin 3A (Sema3A) acts as an attractant for TAMs by triggering vascular endothelial growth factor receptor 1 phosphorylation through the associated holoreceptor, composed of Neuropilin-1 (Nrp1) and PlexinA1/PlexinA4.
Journal ArticleDOI
Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
Mathias Wenes,Min Shang,Mario Di Matteo,Jermaine Goveia,Rosa Martín-Pérez,Jens Serneels,Hans Prenen,Bart Ghesquière,Peter Carmeliet,Massimiliano Mazzone +9 more
TL;DR: It is proved that the anti-tumor effect of mTOR inhibitors is partly countered by the deleterious outcome of these drugs on TAMs, providing a functional link between TAM metabolism and tumor angiogenesis.
Journal ArticleDOI
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
Yukiji Takeda,Sandra Costa,Estelle Delamarre,Carmen Roncal,Rodrigo Leite de Oliveira,Mario Leonardo Squadrito,Veronica Finisguerra,Sofie Deschoemaeker,Françoise Bruyère,Mathias Wenes,Alexander Hamm,Jens Serneels,Julie Magat,Tapan Bhattacharyya,Tapan Bhattacharyya,Andrey Anisimov,Bénédicte F. Jordan,Kari Alitalo,Patrick H. Maxwell,Bernard Gallez,Zhen W. Zhuang,Yoshihiko Saito,Michael Simons,Michele De Palma,Massimiliano Mazzone +24 more
TL;DR: Unraveling how PHD2 regulates arteriogenesis and artery homeostasis by controlling a specific differentiation state in macrophages is unraveled and new treatment options for ischaemic disorders are suggested.
Journal ArticleDOI
Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment
Andrea Casazza,G Di Conza,Mathias Wenes,Veronica Finisguerra,Sofie Deschoemaeker,Massimiliano Mazzone +5 more
TL;DR: The emerging link between tumor stroma and hypoxia is discussed, and how this complexity is translated at the molecular level is discussed.
Journal ArticleDOI
FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis
Len Verbeke,Inge Mannaerts,Robert Schierwagen,Olivier Govaere,Sabine Klein,Ingrid Vander Elst,Petra Windmolders,Ricard Farré,Mathias Wenes,Massimiliano Mazzone,Frederik Nevens,Leo A. van Grunsven,Jonel Trebicka,Wim Laleman +13 more
TL;DR: Preventative and therapeutic effects of FXR agonist obeticholic acid (OCA) inhibits hepatic inflammation in toxic cirrhotic rats resulting in decreased HSC activation and fibrosis.