D
Daniela Dettori
Researcher at University of Turin
Publications - 21
Citations - 1941
Daniela Dettori is an academic researcher from University of Turin. The author has contributed to research in topics: Stromal cell & Metastasis. The author has an hindex of 15, co-authored 20 publications receiving 1714 citations. Previous affiliations of Daniela Dettori include Katholieke Universiteit Leuven & Flanders Institute for Biotechnology.
Papers
More filters
Journal ArticleDOI
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Massimiliano Mazzone,Massimiliano Mazzone,Daniela Dettori,Daniela Dettori,Daniela Dettori,Rodrigo Leite de Oliveira,Rodrigo Leite de Oliveira,Sonja Loges,Sonja Loges,Thomas Schmidt,Thomas Schmidt,Bart Jonckx,Bart Jonckx,Ya Min Tian,Anthony A. Lanahan,Patrick J. Pollard,Carmen Ruiz de Almodovar,Carmen Ruiz de Almodovar,Frederik De Smet,Frederik De Smet,Stefan Vinckier,Stefan Vinckier,Julián Aragonés,Julián Aragonés,Koen Debackere,Koen Debackere,Aernout Luttun,Sabine Wyns,Sabine Wyns,Bénédicte F. Jordan,Alberto Pisacane,Bernard Gallez,Maria Grazia Lampugnani,Elisabetta Dejana,Michael Simons,Peter J. Ratcliffe,Patrick H. Maxwell,Peter Carmeliet,Peter Carmeliet +38 more
TL;DR: In this paper, the role of endothelial PHD2 in vessel shaping by implanting tumors in mice was investigated. But, the authors did not find that PHD deficiency did not affect vessel density or lumen size.
Journal ArticleDOI
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
Sara Van de Veire,Ingeborg Stalmans,Femke Heindryckx,Hajimu Oura,Annemilaï Tijeras-Raballand,Thomas Schmidt,Sonja Loges,Imke Albrecht,Bart Jonckx,Stefan Vinckier,Christophe Van Steenkiste,Sonia Tugues,Sonia Tugues,Charlotte Rolny,Maria De Mol,Daniela Dettori,Patricia Hainaud,Lieve Coenegrachts,Jean Olivier Contreres,Tine Van Bergen,Henar Cuervo,Wei Hong Xiao,Carole Le Henaff,Ian Buysschaert,Behzad Kharabi Masouleh,Anja Geerts,Tibor Schomber,Philippe Bonnin,Vincent Lambert,Jurgen Haustraete,Serena Zacchigna,Jean-Marie Rakic,Wladimiro Jiménez,Agnès Noël,Mauro Giacca,Isabelle Colle,Jean-Michel Foidart,Gérard Tobelem,Manuel Morales-Ruiz,José Vilar,Patrick H. Maxwell,Stanley A. Vinores,Stanley A. Vinores,Geert Carmeliet,Mieke Dewerchin,Lena Claesson-Welsh,Evelyne Dupuy,Hans Van Vlierberghe,Gerhard Christofori,Massimiliano Mazzone,Michael Detmar,Desire Collen,Peter Carmeliet +52 more
TL;DR: It is shown that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease and warrant further testing of anti-PlGF therapies.
Journal ArticleDOI
AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs
Federica Collino,Stefania Bruno,Danny Incarnato,Daniela Dettori,Francesco Neri,Paolo Provero,Margherita Alba Carlotta Pomatto,Salvatore Oliviero,Ciro Tetta,Peter J. Quesenberry,Giovanni Camussi +10 more
TL;DR: MicroRNA depletion in mesenchymal stromal cells and extracellular vesicles significantly reduced their intrinsic regenerative potential in AKI, suggesting a critical role of microRNAs in recovery after AKI.
Journal ArticleDOI
TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway.
Francesco Neri,Daniela Dettori,Danny Incarnato,Anna Krepelova,Stefania Rapelli,Mara Maldotti,Caterina Parlato,Panagiotis Paliogiannis,Salvatore Oliviero +8 more
TL;DR: It is reported that TET1 is downregulated in colon tumours from the initial stage and the DNA hydroxymethylation mediated by Tet1 controlling the WNT signalling is a key player of tumour growth.
Journal ArticleDOI
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity
Rodrigo Leite de Oliveira,Sofie Deschoemaeker,Anne-Theres Henze,Koen Debackere,Veronica Finisguerra,Yukiji Takeda,Carmen Roncal,Daniela Dettori,Evelyne Tack,Yannick Jönsson,Lorenzo Veschini,Annelies Peeters,Andrey Anisimov,Matthias Hofmann,Kari Alitalo,Myriam Baes,Jan D'hooge,Peter Carmeliet,Massimiliano Mazzone +18 more
TL;DR: It is shown that tumor vessel normalization by genetic inactivation of Phd2 increases the delivery of chemotherapeutics to the tumor and, hence, their antitumor and antimetastatic effect, regardless of combined inhibition of PhD2 in cancer cells.