Annemieke De Wilde

TL;DR: The first version of the Standard PREanalytical Code (SPREC) was developed in 2009 by the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group to facilitate documentation and communication of the most important preanalytical quality parameters of different types of biospecimens used for research.

TL;DR: A correlation with prognosis in favour of Evans et al’ definition as a tool for cachexia diagnosis is presented, which means that weight loss and BMI decline are both key factors in patients with cancer leading to cachexia but less decisive as stated by Fearon et al.

TL;DR: Pre-clinical data and early clinical trials showed the promising efficacy of a new class of ALK-inhibitors in overcoming acquired resistance, and the inhibition of the molecular chaperone, HSP90, represents another promising strategy to overcome crizotinib resistance in AlK-rearranged NSCLC.

TL;DR: Quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research are presented.

TL;DR: An international PT program has been developed and provided to biobanks and other laboratories that perform specific tests to qualify different types of biospecimens, and supports the development of biobank quality assurance by providing the possibility to assess biobanking laboratory performance and useful insights into biob bank laboratory method performance characteristics and thus fulfill the demands from accreditation authorities.