Cachexia in cancer: what is in the definition?
Greetje Vanhoutte,Mick van de Wiel,Kristin Wouters,Michaël Sels,Linda Bartolomeeussen,Sven De Keersmaecker,Caroline Verschueren,Veronique De Vroey,Annemieke De Wilde,Elke Smits,Kin Jip Cheung,Liesbeth De Clerck,Petra Aerts,Didier Baert,Caroline Vandoninck,Sofie Kindt,Sofie Schelfhaut,Marc Vankerkhoven,Annelies Troch,Lore Ceulemans,Hanne Vandenbergh,Sven Leys,Tim Rondou,Elke Dewitte,Kristel Maes,Patrick Pauwels,Benedicte Y. De Winter,Luc Van Gaal,Dirk Ysebaert,Marc Peeters +29 more
TLDR
A correlation with prognosis in favour of Evans et al’ definition as a tool for cachexia diagnosis is presented, which means that weight loss and BMI decline are both key factors in patients with cancer leading to cachexia but less decisive as stated by Fearon et al.Abstract:
Objective This study aimed to provide evidence-based results on differences in overall survival (OS) rate to guide the diagnosis of cancer cachexia. Design Data collection and clinical assessment was performed every 3 months (5 visits): baseline data, muscle strength, nutritional and psychosocial status. 2 definitions on cachexia using different diagnostic criteria were applied for the same patient population. Fearon et al's definition is based on weight loss, body mass index (BMI) and sarcopenia. Evans et al nuances the contribution of sarcopenia and attaches additional attention to abnormal biochemistry parameters, fatigue and anorexia. The mean OS rates were compared between patients with and without cachexia for both definitions. Results Based on the population of 167 patients who enrolled, 70% developed cachexia according to Fearon et al's definition and 40% according to Evans et al's definition. The OS in the cachectic population is 0.97 and 0.55 years, respectively. The difference in OS between pat...read more
Citations
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Cancer cachexia: Diagnosis, assessment, and treatment.
Mohammad Amin Sadeghi,Mahsa Keshavarz-Fathi,Vickie E. Baracos,Jann Arends,Maryam Mahmoudi,Nima Rezaei,Nima Rezaei +6 more
TL;DR: This review covers the diagnosis, assessment, and treatment of cancer cachexia; the elements impeding the formulation of a standard management guideline; and future directions of research for the improvement and standardization of current treatment procedures.
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GLIM Criteria Using Hand Grip Strength Adequately Predict Six-Month Mortality in Cancer Inpatients.
Victoria Contreras-Bolívar,Francisco José Sánchez-Torralvo,María Ruiz-Vico,Inmaculada González-Almendros,Manuel Barrios,Susana Padín,Emilio Alba,Gabriel Olveira +7 more
TL;DR: SGA and GLIM criteria, especially with HGS, are useful tools to diagnose malnutrition and have a similar predictive value regarding six-month mortality in cancer inpatients.
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A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis.
Songwei Yang,Shifeng Chu,Shifeng Chu,Yan Gao,Qidi Ai,Qidi Ai,Yingjiao Liu,Yingjiao Liu,Xun Li,Xun Li,Nai-Hong Chen,Nai-Hong Chen +11 more
TL;DR: The main purpose of this review is to analyze the possible pathogenesis of CRF and recommend future research that will clarify CRF pathogenesis and facilitate the formulation of new treatment options.
Journal ArticleDOI
Sarcopenia, Malnutrition, and Cachexia: Adapting Definitions and Terminology of Nutritional Disorders in Older People with Cancer.
Delky Meza-Valderrama,Ester Marco,Vanesa Dávalos-Yerovi,Maria Dolors Muns,Marta Tejero-Sánchez,Esther Duarte,Dolores Sánchez-Rodríguez +6 more
TL;DR: The recent publication of the revised Consensus on definition and diagnosis of sarcopenia (EWGSOP2) and the Global Leadership Initiative on Malnutrition (GLIM) criteria changed the approach to research on sarcopenias and malnutrition as discussed by the authors.
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Associations of low handgrip strength with cancer mortality: a multicentre observational study
Cheng-Le Zhuang,Feng-Min Zhang,Wei Li,Kunhua Wang,Hongxia Xu,Chunhua Song,Zengqing Guo,Hanping Shi +7 more
TL;DR: The objective of this study was to establish sex‐specific cut‐off points for Chinese cancer patients and investigate the effect of low HGS on cancer mortality.
References
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Journal ArticleDOI
Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People
Alfonso J. Cruz-Jentoft,Jean-Pierre Baeyens,Jürgen M. Bauer,Yves Boirie,Tommy Cederholm,Francesco Landi,Finbarr C. Martin,Jean-Pierre Michel,Yves Rolland,Stéphane M. Schneider,Eva Topinkova,Maurits Vandewoude,Mauro Zamboni +12 more
TL;DR: The European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria for age-related sarcopenia as discussed by the authors.
Journal ArticleDOI
Definition and classification of cancer cachexia: an international consensus
Kenneth C. H. Fearon,Florian Strasser,Stefan D. Anker,Ingvar Bosaeus,Eduardo Bruera,Robin L. Fainsinger,Aminah Jatoi,Charles L. Loprinzi,Neil MacDonald,Giovanni Mantovani,Mellar P. Davis,Maurizio Muscaritoli,Faith D. Ottery,Lukas Radbruch,Paula Ravasco,Declan Walsh,Andrew Wilcock,Stein Kaasa,Vickie E. Baracos +18 more
TL;DR: A framework exists on a framework for the definition and classification of cancer cachexia, a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment.
Journal ArticleDOI
Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability.
TL;DR: To establish the prevalence of sarc Openia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons is established.
Journal ArticleDOI
Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials.
TL;DR: The screening system appears to be able to distinguish between trials with a positive effect vs no effect, and it can therefore probably also identify patients who are likely to benefit from nutritional support.
Journal ArticleDOI
Cachexia: a new definition.
William J. Evans,John E. Morley,Josep M. Argilés,Connie W. Bales,Vickie E. Baracos,Denis Guttridge,Aminah Jatoi,Kamyar Kalantar-Zadeh,H. Lochs,Giovanni Mantovani,Daniel L. Marks,William E. Mitch,Maurizio Muscaritoli,Armine Najand,Piotr Ponikowski,Filippo Rossi Fanelli,Morrie Schambelan,Annemie M. W. J. Schols,Michael W. Schuster,David R. Thomas,Robert R. Wolfe,Stefan D. Anker +21 more
TL;DR: The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders).
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