A
Antonella Antignani
Researcher at Laboratory of Molecular Biology
Publications - 30
Citations - 825
Antonella Antignani is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Antibody. The author has an hindex of 14, co-authored 26 publications receiving 748 citations. Previous affiliations of Antonella Antignani include National Institutes of Health.
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Journal ArticleDOI
How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane
TL;DR: Bcl-2 family members in flies and worms regulate apoptosis by mechanisms seemingly unrelated to membrane permeabilization, leaving a unifying model for the biochemical activity of this protein family unknown.
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Immunotoxins: The Role of the Toxin
TL;DR: The utility of protein toxins, of both bacterial and plant origin, joined to antibodies for targeting cancer cells are discussed, both for treating human disease and probes of cellular function.
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Conformation of BCL-XL upon Membrane Integration
Yong Yao,Lynn M. Fujimoto,Nathan Hirshman,Andrey A. Bobkov,Antonella Antignani,Richard J. Youle,Francesca M. Marassi +6 more
TL;DR: It is shown that the C-terminus interacts with a conserved surface groove in the water-soluble state of the protein and inserts across the phospholipid bilayer in the membrane-bound state.
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ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol.
Roberta Traini,Gal Ben-Josef,Diana V. Pastrana,Elizabeth Moskatel,Ashima K. Sharma,Antonella Antignani,David J. FitzGerald +6 more
TL;DR: ABT-737 might be particularly well suited for enhancing the activity of immunotoxins that translocate from the ER to the cell cytosol, because of its activity in the ER, and possible mechanisms of resistance.
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Bax activates endophilin B1 oligomerization and lipid membrane vesiculation.
Tatiana K. Rostovtseva,Hacene Boukari,Antonella Antignani,Brian Shiu,Soojay Banerjee,Albert Neutzner,Richard J. Youle +6 more
TL;DR: Activity of purified Bax protein to induce cell-free assembly of Endo B1 may reflect its activity in cells that regulates apoptosis and/or mitochondrial fusion.