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Antonia Kwan
Researcher at University of California, San Francisco
Publications - 12
Citations - 1037
Antonia Kwan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Severe combined immunodeficiency & Newborn screening. The author has an hindex of 7, co-authored 9 publications receiving 837 citations.
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Journal ArticleDOI
Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States
Antonia Kwan,Roshini S. Abraham,Robert Currier,Amy Brower,Karen Andruszewski,Jordan K. Abbott,Mei W. Baker,Mark Ballow,Louis Bartoshesky,Francisco A. Bonilla,Charles D. Brokopp,Edward G. Brooks,Michele Caggana,Jocelyn Celestin,Joseph A. Church,Anne Marie Comeau,James A. Connelly,Morton J. Cowan,Charlotte Cunningham-Rundles,Trivikram Dasu,Nina Dave,Maria Teresa de la Morena,Ulrich A. Duffner,Chin-To Fong,Lisa R. Forbes,Lisa R. Forbes,Debra Freedenberg,Erwin W. Gelfand,Jaime E. Hale,I. Celine Hanson,I. Celine Hanson,Beverly N. Hay,Diana Hu,Anthony J. Infante,Daisy Johnson,Neena Kapoor,Denise M. Kay,Donald B. Kohn,Rachel Lee,Heather K. Lehman,Zhili Lin,Fred Lorey,Aly Abdel-Mageed,Adrienne Manning,Sean A. McGhee,Sean A. McGhee,Theodore B. Moore,Stanley J. Naides,Luigi D. Notarangelo,Jordan S. Orange,Jordan S. Orange,Sung-Yun Pai,Matthew H. Porteus,Matthew H. Porteus,Ray Rodriguez,Neil Romberg,John M. Routes,Mary Ruehle,Arye Rubenstein,Carlos A. Saavedra-Matiz,Ginger Scott,Patricia M. Scott,Elizabeth Secord,Christine M. Seroogy,William T. Shearer,William T. Shearer,Subhadra Siegel,Stacy K. Silvers,E. Richard Stiehm,Robert W. Sugerman,John L. Sullivan,Susan Tanksley,Millard L. Tierce,James W. Verbsky,Beth Vogel,Rosalyn Walker,Kelly Walkovich,Jolan E. Walter,Richard L. Wasserman,Michael S. Watson,Geoffrey A. Weinberg,Leonard B. Weiner,Heather Wood,Anne B. Yates,Jennifer M. Puck +84 more
TL;DR: Newborn screening in 11 programs in the United States identified SCID in 1 in 58,000 infants, with high survival, and the usefulness of detection of non-SCID T-cell lymphopenia by the same screening remains to be determined.
Journal ArticleDOI
Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: Results of the first 2 years
Antonia Kwan,Joseph A. Church,Morton J. Cowan,Rajni Agarwal,Neena Kapoor,Donald B. Kohn,David B. Lewis,Sean A. McGhee,Theodore B. Moore,E. Richard Stiehm,Matthew H. Porteus,Constantino P. Aznar,Robert Currier,Fred Lorey,Jennifer M. Puck +14 more
TL;DR: The first 2 years of population-based newborn screening (NBS) for severe combined immunodeficiency (SCID) in California were reported in this paper, where a high-throughput T-cell receptor excision circles (TREC) quantitative PCR assay with DNA isolated from routine dried blood spots was developed.
Journal ArticleDOI
History and current status of newborn screening for severe combined immunodeficiency.
Antonia Kwan,Jennifer M. Puck +1 more
TL;DR: The development of newborn screening forSCID, the biology of the TREC test, its current implementation in the U.S., new findings for SCID in the newborn screening era, and future directions are reviewed.
Journal ArticleDOI
Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B
Divya Punwani,Yong Zhang,Jason Yu,Morton J. Cowan,Sadhna Rana,Antonia Kwan,Aashish N. Adhikari,Carlos Lizama,Bryce A. Mendelsohn,Shawn P. Fahl,Ajithavalli Chellappan,Rajgopal Srinivasan,Steven E. Brenner,David L. Wiest,Jennifer M. Puck +14 more
TL;DR: Newborn screening facilitated the identification and treatment of a previously unknown cause of human SCID and revealed a prethymic role for BCL11B in hematopoietic progenitors.
Journal ArticleDOI
Newborn Screening for SCID Identifies Patients with Ataxia Telangiectasia
Jacob Mallott,Antonia Kwan,Joseph A. Church,Diana Gonzalez-Espinosa,Fred Lorey,Ling Fung Tang,Uma Sunderam,Sadhna Rana,Rajgopal Srinivasan,Steven E. Brenner,Jennifer M. Puck +10 more
TL;DR: Although there is no current cure for the progressive neurological impairment of AT, early detection permits avoidance of infectious complications, while providing information for families regarding reproductive recurrence risks and increased cancer risks in patients and carriers.