Arnold J. Levine

TL;DR: The p53 protein is a transcription factor that prevents tumors from developing as discussed by the authors, however, mutations in the DNA binding domain of the TP53 gene contribute to tumor formation and can produce a wide distribution in the transcriptional capabilities of the mutant p53 proteins with over four logs differences in the efficiencies of forming cancers in many diverse tissue types.

TL;DR: The last 15 years have witnessed a conceptual breakthrough in understanding of the molecular and genetic basis of the origins of neoplasia in humans, methodically, experiment by experiment, with no one observation yielding the entire picture.

TL;DR: This data indicates that a high-expression of IGF-1 in the blood of patients with parkinson disease is a potential biomarker of Parkinson's disease and the use of RHEB to correct for this problem is warranted.

TL;DR: Viral DNA synthesized prior to the addition of cycloheximide did not participate, or participated to only a small extent, in the formation of SV40 oligomeric DNA observed after cyclo heximide treatment, and the available evidence indicates that SV 40 oligomers were synthesized by the replication of viral DNA in the absence of protein synthesis.

TL;DR: These studies show that transgenic mice expressing SV40 T antigen are capable of responding to determinants not shared between JCV and SV 40 T antigen.