Arnold J. Levine

TL;DR: The p53 pathway is composed of hundreds of genes and their products that respond to a wide variety of stress signals that play a role in protection from cancers, therapy and integrating the homeostatic mechanisms of stress management and fidelity in a cell and organism.

TL;DR: The p53 pathway has been shown to mediate cellular stress responses; p53 can initiate DNA repair, cell-cycle arrest, senescence and, importantly, apoptosis and this work focuses on how best to use knowledge of this pathway to tailor current therapies and develop novel ones.

TL;DR: A p53-regulated gene product, TSAP6, was shown to enhance exosome production in cells undergoing a p53 response to stress, indicating that the p53 pathway regulates the production of exosomes into the medium and these vesicles can communicate with adjacent cells and even cells of the immune system.

TL;DR: Using an oligonucleotide array containing sequences complementary to approximately 3200 full-length human cDNAs and 3400 expressed sequence tags, mRNA expression patterns were probed in colon adenocarcinomas and 4 adenomas, generating a phylogenetic tree that appropriately represented the clinical relationship between the three tissue types included in the analysis.

TL;DR: The results of this study demonstrate that the nature of the p53 response in diverse mRNA species depends on the levels of p53 protein in a cell, the type of inducing agent or event, and the cell type employed.