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Arnold J. Levine
Researcher at Institute for Advanced Study
Publications - 493
Citations - 122094
Arnold J. Levine is an academic researcher from Institute for Advanced Study. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 139, co-authored 485 publications receiving 116005 citations. Previous affiliations of Arnold J. Levine include Harvard University & Affymetrix.
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Journal ArticleDOI
Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF
Motonari Uesugi,Origene Nyanguile,Origene Nyanguile,Hua Lu,Hua Lu,Arnold J. Levine,Arnold J. Levine,Gregory L. Verdine,Gregory L. Verdine +8 more
TL;DR: Identification of the two hydrophobic residues that make nonpolar contacts suggests a general recognition motif of acidic activation domains for hTAFII31, a human TFIID TATA box – binding protein-associated factor.
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Allele Specific p53 Mutant Reactivation
TL;DR: Mechanistic studies reveal that NSC319726 restores WT structure and function to the p53(R175) mutant and is identified as a lead compound for p53-targeted drug development.
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The Origins and Evolution of the p53 Family of Genes
Vladimir A. Belyi,Prashanth Ak,Elke Markert,Haijian Wang,Wenwei Hu,Anna M. Puzio-Kuter,Arnold J. Levine +6 more
TL;DR: A common ancestor to the three p53 family members of human genes p53, p63, and p73 is first detected in the evolution of modern-day sea anemones, in which both structurally and functionally it acts to protect the germ line from genomic instabilities in response to stresses.
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The mdm-2 gene is induced in response to UV light in a p53-dependent manner
TL;DR: The time of induction of mdm-2 in cells treated with UV light correlates with recovery of normal rates of DNA synthesis, presumably after DNA repair, and indicates a possible role for mdm -2 in cell cycle progression.
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Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: Implications for latency
TL;DR: It is proposed that herpesviruses use microRNA-mediated suppression of immediate-early genes as part of their strategy to enter and maintain latency.