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Arnold J. Levine
Researcher at Institute for Advanced Study
Publications - 493
Citations - 122094
Arnold J. Levine is an academic researcher from Institute for Advanced Study. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 139, co-authored 485 publications receiving 116005 citations. Previous affiliations of Arnold J. Levine include Harvard University & Affymetrix.
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Journal ArticleDOI
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
TL;DR: An in vitro 3D multicellular spheroids model using the human NET cell lines to examine the effect of therapeutic drugs is developed, and an example of a single drug's effect on growth and proliferation of the NET sp Heroids is displayed.
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A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer
Diptee Kulkarni,Alexei Vazquez,Bruce G. Haffty,Elisa V. Bandera,Wenwei Hu,Yvonne Sun,Deborah Toppmeyer,Arnold J. Levine,Arnold J. Levine,Kim M. Hirshfield +9 more
TL;DR: No association was seen in ER-positive ductal cancers suggesting that the SNP in MDM4 only has a functional association in ER -negative breast cancer.
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Stem cell biology meets p53
TL;DR: Often called “the guardian of the genome,” p53 may also be the guardian of stable development.
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Insights into immune system development and function from mouse T-cell repertoires.
Zachary Sethna,Yuval Elhanati,Yuval Elhanati,Crissy Dudgeon,Curtis G. Callan,Arnold J. Levine,Thierry Mora,Aleksandra M. Walczak +7 more
TL;DR: By analyzing T-cell receptor (TCR) sequence repertoires taken from the blood and thymus of mice of different ages, changes in the VDJ recombination process that occur from embryo to young adult are quantified and a rapid increase with age in the number of random insertions and a dramatic increase in diversity are found.
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Biochemical criteria for the in vitro differentiation of embryoid bodies produced by a transplantable teratoma of mice. The production of acetylcholine esterase and creatine phosphokinase by teratoma cells
TL;DR: When embryoid bodies are grown in suspension culture in vitro, they undergo only a limited amount of morphological development, but when they are permitted to attach to the surface of a culture dish, a wide variety of new morphological cell types appear.