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Arnold J. Levine
Researcher at Institute for Advanced Study
Publications - 493
Citations - 122094
Arnold J. Levine is an academic researcher from Institute for Advanced Study. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 139, co-authored 485 publications receiving 116005 citations. Previous affiliations of Arnold J. Levine include Harvard University & Affymetrix.
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Journal ArticleDOI
Detection of functional single-nucleotide polymorphisms that affect apoptosis.
Sandra L. Harris,German Gil,Harlan Robins,Wenwei Hu,Kim M. Hirshfield,Elisabeth E. Bond,Gareth L. Bond,Arnold J. Levine +7 more
TL;DR: Human EBV-transformed B lymphocyte cell lines were used to measure the apoptotic response of individuals to gamma radiation and the assay is capable of detecting significant effects of SNPs in two genes, MDM2 and AKT1, whose products are involved in controlling the p53 pathway and cellular response to DNA damage.
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Identification and mapping of Epstein-Barr virus early antigens and demonstration of a viral gene activator that functions in trans.
Kam-Meng Wong,Arnold J. Levine +1 more
TL;DR: A test for several possible functions of these antigens showed that the BMLF1 antigen had the ability to activate or enhance, in trans, the level of expression of a gene under the control of the adenovirus early region 3 promoter or the simian virus 40 early promoter in the absence of its cis-acting enhancer.
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Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice.
TL;DR: A line of transgenic mice containing the simian virus 40 (SV40) large tumor antigen gene under the control of the viral enhancer-promoter expressed this viral protein in the brains of these mice within the first 2 weeks after birth as mentioned in this paper.
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Identification of the adenovirus early proteins and their genomic map positions
TL;DR: Six different group C adenovirus transformed hamster cell lines were employed to produce tumors in hamsters and the sera from these animals were used to immunoprecipitate [35S]methionine-labeled adenvirus induced tumor antigens from virus infected and transformed cells.
Relationship between Simian Virus 40LargeTumorAntigen Expression andTumorFormation inTransgenic Mice
TL;DR: It is suggested that low levels of tumor antigen are present before detectable pathology and the level of T antigen per cell is higher in rapidly growing late-stage tumors (older than 90 days).