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Arnold J. Levine
Researcher at Institute for Advanced Study
Publications - 493
Citations - 122094
Arnold J. Levine is an academic researcher from Institute for Advanced Study. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 139, co-authored 485 publications receiving 116005 citations. Previous affiliations of Arnold J. Levine include Harvard University & Affymetrix.
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Transformation by adenovirus early region 2A temperature-sensitive mutants and their revertants
TL;DR: A temperature-sensitive mutant of adenovirus type 5 whose alteration maps in the structural gene for the viral DNA binding protein that form plaques at 39° in HeLa cells has been isolated.
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DNA replication in SV40-infected cells: V. Circular and catenated oligomers of SV40 DNA
Rudolf Jaenisch,Arnold J. Levine +1 more
TL;DR: Intracellular viral DNA from African green monkey cells infected with simian virus 40 (SV40) has been isolated by repeated sedimentation through alkaline sucrose gradients and the occurrence of circular oligomers and catenated SV40 DNA molecules has been demonstrated.
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Chemosensitivity Profiles Identify Polymorphisms in the p53 Network Genes 14-3-3τ and CD44 That Affect Sarcoma Incidence and Survival
Alexei Vazquez,Lukasz F. Grochola,Elisabeth E. Bond,Arnold J. Levine,Helge Taubert,Thomas Müller,Peter Würl,Gareth L. Bond +7 more
TL;DR: These findings define genetic markers in 14-3-3tau and CD44 that might improve the treatment and prognosis of soft-tissue sarcomas and identify 7 SNPs that exhibit allelic differences in cellular responses to a large panel of cytotoxic chemotherapeutic agents.
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Adenovirus-infected, cell-specific, DNA-binding proteins.
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The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors.
Chung Wong,Saurabh V. Laddha,Laura H. Tang,Evan Vosburgh,Arnold J. Levine,E Normant,P Sandy,Chris R. Harris,Chang S. Chan,Eugenia Y. Xu +9 more
TL;DR: The data suggest that targeting MYC with a BETi may increase the therapeutic benefits of rapalogs in human PanNET patients and provide a novel clinical strategy for PanNETs, and possibly for other tumors as well.